Fluoroalkyl fragments are ubiquitous motifs in pharmaceuticals and agrochemicals, but their introduction to a given molecule typically involves expensive or difficult-to-handle reagents. Now, the photocatalysed hydrofluoroalkylation of alkenes has been achieved using simple and readily available fluoroalkyl carboxylic acids.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Purser, S., Moore, P. R., Swallow, S. & Gouverneur, V. Chem. Soc. Rev. 37, 320–330 (2008).
Shibata, N., Matsnev, A. & Cahard, D. Beilstein J. Org. Chem. https://doi.org/10.3762/bjoc.6.65 (2010).
López, S. E. & Salazar, J. J. Fluor. Chem. 156, 73–100 (2013).
Depecker, C., Marzouk, H., Trevin, S. & Devynck, J. New J. Chem. 23, 739–742 (1999).
Roth, H. G., Romero, N. A. & Nicewicz, D. A. Synlett. 27, 714–723 (2016).
Prier, C. K., Rankic, D. A. & MacMillan, D. W. C. Chem. Rev. 113, 5322–5363 (2013).
Xuan, J., Zhang, Z.-G. & Xiao, W.-J. Angew. Chem. Int. Ed. 54, 15632–15641 (2015).
Bian, K.-J. et al. Nat. Chem. https://doi.org/10.1038/s41557-023-01365-0 (2023).
Juliá, F. ChemCatChem. 14, e2022009 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Juliá, F. From feedstock to pharmaceuticals. Nat. Chem. 15, 1657–1658 (2023). https://doi.org/10.1038/s41557-023-01377-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41557-023-01377-w