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Synthetic methodology

From feedstock to pharmaceuticals

Fluoroalkyl fragments are ubiquitous motifs in pharmaceuticals and agrochemicals, but their introduction to a given molecule typically involves expensive or difficult-to-handle reagents. Now, the photocatalysed hydrofluoroalkylation of alkenes has been achieved using simple and readily available fluoroalkyl carboxylic acids.

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Fig. 1: Iron photocatalysis enables the hydrofluoroalkylation of alkenes using fluoroalkyl carboxylic acids as reagents.

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Correspondence to Fabio Juliá.

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Juliá, F. From feedstock to pharmaceuticals. Nat. Chem. 15, 1657–1658 (2023). https://doi.org/10.1038/s41557-023-01377-w

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