Review Article
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Open Access
Featured
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Review Article
| Open Access
Interstitial fluid-based wearable biosensors for minimally invasive healthcare and biomedical applications
There is growing interest in biosensors that detect biomarkers in interstitial fluid. This Review provides an overview of recent developments on interstitial fluid biosensors, including device fabrication and sensing mechanisms, and outstanding challenges faced.
- Zixiong Wu
- , Zheng Qiao
- & Chwee Teck Lim
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Article
| Open Access
Durable plasma-mediated zwitterionic grafting on polymeric surfaces for implantable medical devices
Poor material biocompatibility of implanted medical devices endangers patient safety and impairs device functionality. Here, durable zwitterion grafts attached onto polymeric surfaces via plasma functionalization lead to superhydrophilic materials for safer and more durable devices.
- Matthew Crago
- , Richard Tan
- & Sina Naficy
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Perspective
| Open Access
Towards a digitally connected body for holistic and continuous health insight
Wearable electronics provide opportunities for personalized health monitoring and treatment. This Perspective addresses challenges in the field, including material selection for devices, device integration strategies, and public adoption factors.
- Philipp Gutruf
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Article
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Design and evaluation of multi-core raspberry-like platinum nanoparticles for enhanced photothermal treatment
Platinum nanoparticles are promising candidates for enhancing radiotherapy sensitivity. Here, platinum-based nanomaterials with a multi-core structure show efficient near-infrared photothermal treatment on glioblastoma tumoroids with good biostability.
- Erwann Guénin
- , Alexandre Fromain
- & Claire Wilhelm
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Article
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Boosting inhibition performance of natural polyphenols for the prevention of calcium oxalate kidney stones through synergistic cooperativity
Binary drug combinations can be used for cooperative therapy. Here, binary inhibitor combinations of citrate with natural polyphenols can boost the inhibitory efficacy of calcium oxalate monohydrate crystallization, a primary component of kidney stones.
- Si Li
- , Donghui Zhou
- & Junbo Gong
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Article
| Open Access
In vivo engraftment into the cornea endothelium using extracellular matrix shrink-wrapped cells
Tissue regeneration by injecting cells into the damaged area is a common clinical treatment, but is not always affective. Here, a shrink-wrap-like process is reported for corneal endothelial cells, allowing them to be engrafted into the corneal endothelium of a rabbit animal model.
- Rachelle N. Palchesko
- , Yiqin Du
- & Adam W. Feinberg
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Review Article
| Open Access
Design principles and biological applications of red-emissive two-photon carbon dots
Carbon dots are suitable for a range of biological applications due to their unique physicochemical properties and biological behavior. This Review summarizes research related to the emerging field of red-emissive two-photon carbon dots for bioimaging, biosensing, and phototherapeutic applications.
- Pooria Lesani
- , Aina Hazeera Mohamad Hadi
- & Hala Zreiqat
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Article
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Microstructure analysis and image-based modelling of face masks for COVID-19 virus protection
Face masks are key for slowing the spread of COVID-19. Here, the microstructure of three common masks is determined by x-ray tomography, combined with image-based modelling of droplet permeability, revealing that N95 masks are best for droplet filtration.
- Wenjia Du
- , Francesco Iacoviello
- & Paul R. Shearing
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Article
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Extended gate field-effect-transistor for sensing cortisol stress hormone
Wearable, real-time devices that can monitor hormones are important for personalized healthcare. Here, a platinum/graphene aptamer extended gate field effect transistor is shown to detect cortisol, the primary stress hormone, in physiological fluid.
- Shokoofeh Sheibani
- , Luca Capua
- & Adrian M. Ionescu
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Article
| Open Access
Recombinant collagen polypeptide as a versatile bone graft biomaterial
Synthetic bone graft materials are needed due to aging societies. Here, biodegradable and versatile recombinant collagen polypeptide scaffolds are engineered to induce bone regeneration in pre-clinical animal models.
- Hideo Fushimi
- , Takahiro Hiratsuka
- & Ichiro Nishimura
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Article
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The role of valve stiffness in the insurgence of deep vein thrombosis
Deep vein thrombosis is the clotting of blood in deep veins. Here, a microfluidic device containing flexible valves fabricated in-situ is used to investigate the effects of blood flow conditions and valve elasticity on thrombus formation, revealing the circumstance under which clotting occurs.
- Zoe Schofield
- , Hosam Alden Baksamawi
- & Daniele Vigolo
Recent developments in wearable breath sensors for healthcare monitoring