Genetics

Genetics is the branch of science concerned with genes, heredity, and variation in living organisms. It seeks to understand the process of trait inheritance from parents to offspring, including the molecular structure and function of genes, gene behaviour in the context of a cell or organism (e.g. dominance and epigenetics), gene distribution, and variation and change in populations.

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News and Comment

  • Comments & Opinion |

    The SARS-CoV-2/COVID-19 pandemic has significantly increased the demand for specific-pathogen-free (SPF) nonhuman primates (NHPs) for development of vaccines and therapeutics, thus straining the supply of these animals for biomedical research studies. Non-SPF animals, which are available in greater numbers and include well-characterized primate species, should be considered in lieu of limited SPF animals for appropriate research studies.

    • Miguel A. Contreras
    • , Matthew E. Arnegard
    •  & Stephanie J. Murphy
    Lab Animal, 1-2
  • News & Views |

    A single dose of an adenine base editor shows promise in treating the ageing-related disease Hutchinson–Gilford progeria syndrome. It corrected the LMNA mutation underlying the disease in patient-derived cells and improved cardiovascular health and lifespan in mice.

    • Luke W. Koblan
    • , Michael R. Erdos
    •  & David R. Liu
  • News & Views |

    An innovative approach to a phase II clinical trial aims to test the effects of multiple targeted treatments simultaneously in participants in the UK National Lung Matrix Trial. The design makes it possible to study small numbers of people with rare mutations in non-small-cell lung tumours.

    • Gary Middleton
  • News |

    Is a trend of auctioning non-fungible tokens based on scientific data a fascinating art fad, an environmental disaster or the future of monetized genomics?

    • Nicola Jones
    Nature 594, 481-482
  • News & Views |

    The Pharmacogenomics Access & Reimbursement Symposium, a landmark event presented by the Golden Helix Foundation and the Pharmacogenomics Access & Reimbursement Coalition (PARC), was a one-day interactive meeting comprised of plenary keynotes from thought leaders across health care that focused on value-based strategies to improve patient access to personalized medicine. Stakeholders including patients, healthcare providers, industry, government agencies, payer organizations, health systems and health policy organizations convened to define opportunities to improve patient access to personalized medicine through best practices, successful reimbursement models, high-quality economic evaluations, and strategic alignment. Session topics included health technology assessment, health economics, health policy, and value-based payment models and innovation.

    • Sara L. Rogers
    • , George P. Patrinos
    •  & Benjamin G. Brown