Gene regulation

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to specific DNA elements to regulate transcription, or mechanisms that modulate translation of mRNA.

Latest Research and Reviews

  • Research |

    A screen of 23 transcriptional cofactors for their ability to activate 72,000 candidate core promoters in Drosophila melanogaster identified distinct compatibility groups, providing insight into mechanisms that underlie the selective activation of transcriptional programs.

    • Vanja Haberle
    • , Cosmas D. Arnold
    • , Michaela Pagani
    • , Martina Rath
    • , Katharina Schernhuber
    •  & Alexander Stark
    Nature, 1-5
  • Reviews |

    For appropriate control of gene expression, enhancers must communicate with the right target genes at the right time, typically over large genomic distances. In this Review, Schoenfelder and Fraser discuss our latest understanding of long-range enhancer–promoter crosstalk, including target-gene specificity, interaction dynamics, protein and RNA architects of interactions, roles of 3D genome organization and the pathological consequences of regulatory rewiring.

    • Stefan Schoenfelder
    •  & Peter Fraser
  • Research | | open

    Polycomb and Trithorax group proteins regulate silent and active gene expression states, but also allow poised states in pluripotent cells. Here the authors present a mathematical model that integrates data on Polycomb/ Trithorax biochemistry into a single coherent framework which predicts that poised chromatin is not bivalent as previously proposed, but is bistable, meaning that the system switches frequently between stable active and silent states.

    • Kim Sneppen
    •  & Leonie Ringrose
  • Research | | open

    CBFB is highly mutated in breast cancers and is known to interact with RUNX proteins to regulate transcription. Here, the authors describe a non-canonical role of CBFB in translation regulation in which it binds to mRNAs through hnRNPK, facilitating translation by eIF4B.

    • Navdeep Malik
    • , Hualong Yan
    • , Nellie Moshkovich
    • , Murali Palangat
    • , Howard Yang
    • , Vanesa Sanchez
    • , Zhuo Cai
    • , Tyler J. Peat
    • , Shunlin Jiang
    • , Chengyu Liu
    • , Maxwell Lee
    • , Beverly A. Mock
    • , Stuart H. Yuspa
    • , Daniel Larson
    • , Lalage M. Wakefield
    •  & Jing Huang
  • Research | | open

    • Lisa Borghini
    • , Eileen Png
    • , Alexander Binder
    • , Victoria J. Wright
    • , Ellie Pinnock
    • , Ronald de Groot
    • , Jan Hazelzet
    • , Marieke Emonts
    • , Michiel Van der Flier
    • , Luregn J. Schlapbach
    • , Suzanne Anderson
    • , Fatou Secka
    • , Antonio Salas
    • , Colin Fink
    • , Enitan D. Carrol
    • , Andrew J. Pollard
    • , Lachlan J. Coin
    • , Taco W. Kuijpers
    • , Federico Martinon-Torres
    • , Werner Zenz
    • , Michael Levin
    • , Martin L. Hibberd
    • , Sonia Davila
    • , Stuart Gormley
    • , Shea Hamilton
    • , Jethro Herberg
    • , Bernardo Hourmat
    • , Clive Hoggart
    • , Myrsini Kaforou
    • , Vanessa Sancho-Shimizu
    • , Amina Abdulla
    • , Paul Agapow
    • , Maeve Bartlett
    • , Evangelos Bellos
    • , Hariklia Eleftherohorinou
    • , Rachel Galassini
    • , David Inwald
    • , Meg Mashbat
    • , Stefanie Menikou
    • , Sobia Mustafa
    • , Simon Nadel
    • , Rahmeen Rahman
    • , Clare Thakker
    • , S. Bokhandi
    • , Sue Power
    • , Heather Barham
    • , N. Pathan
    • , Jenna Ridout
    • , Deborah White
    • , Sarah Thurston
    • , S. Faust
    • , S. Patel
    • , Jenni McCorkell
    • , P. Davies
    • , Lindsey Cratev
    • , Helen Navarra
    • , Stephanie Carter
    • , R. Ramaiah
    • , Rekha Patel
    • , Catherine Tuffrey
    • , Andrew Gribbin
    • , Sharon McCready
    • , Mark Peters
    • , Katie Hardy
    • , Fran Standing
    • , Lauren O’Neill
    • , Eugenia Abelake
    • , Akash Deep
    • , Eniola Nsirim
    • , Louise Willis
    • , Zoe Young
    • , C. Royad
    • , Sonia White
    • , P. M. Fortune
    • , Phil Hudnott
    • , Fernando Álvez González
    • , Ruth Barral-Arca
    • , Miriam Cebey-López
    • , María José Curras-Tuala
    • , Natalia García
    • , Luisa García Vicente
    • , Alberto Gómez-Carballa
    • , Jose Gómez Rial
    • , Andrea Grela Beiroa
    • , Antonio Justicia Grande
    • , Pilar Leboráns Iglesias
    • , Alba Elena Martínez Santos
    • , Nazareth Martinón-Torres
    • , José María Martinón Sánchez
    • , Belén Mosquera Pérez
    • , Pablo Obando Pacheco
    • , Jacobo Pardo-Seco
    • , Sara Pischedda
    • , Irene Rivero Calle
    • , Carmen Rodríguez-Tenreiro
    • , Lorenzo Redondo-Collazo
    • , Sonia Serén Fernández
    • , María del Sol Porto Silva
    • , Ana Vega
    • , Susana Beatriz Reyes
    • , María Cruz León León
    • , Álvaro Navarro Mingorance
    • , Xavier Gabaldó Barrios
    • , Eider Oñate Vergara
    • , Andrés Concha Torre
    • , Ana Vivanco
    • , Reyes Fernández
    • , Francisco Giménez Sánchez
    • , Miguel Sánchez Forte
    • , Pablo Rojo
    • , J. Ruiz Contreras
    • , Alba Palacios
    • , Marisa Navarro
    • , Cristina Álvarez Álvarez
    • , María José Lozano
    • , Eduardo Carreras
    • , Sonia Brió Sanagustín
    • , Olaf Neth
    • , Ma del Carmen Martínez Padilla
    • , Luis Manuel Prieto Tato
    • , Sara Guillén
    • , Laura Fernández Silveira
    • , David Moreno
    • , A. M. Tutu van Furth
    • , M. van der Flier
    • , N. P. Boeddha
    • , G. J. A. Driessen
    • , D. Pajkrt
    • , E. A. M. Sanders
    • , D. van de Beek
    • , A. van der Ende
    • , H. L. A. Philipsen
    • , A. O. A. Adeel
    • , M. A. Breukels
    • , D. M. C. Brinkman
    • , C. C. M. M. de Korte
    • , E. de Vries
    • , W. J. de Waal
    • , R. Dekkers
    • , A. Dings-Lammertink
    • , R. A. Doedens
    • , A. E. Donker
    • , M. Dousma
    • , T. E. Faber
    • , G. P. J. M. Gerrits
    • , J. A. M. Gerver
    • , J. Heidema
    • , J. Homan-van der Veen
    • , M. A. M. Jacobs
    • , N. J. G. Jansen
    • , P. Kawczynski
    • , K. Klucovska
    • , M. C. J. Kneyber
    • , Y. Koopman-Keemink
    • , V. J. Langenhorst
    • , J. Leusink
    • , B. F. Loza
    • , I. T. Merth
    • , C. J. Miedema
    • , C. Neeleman
    • , J. G. Noordzij
    • , C. C. Obihara
    • , A. L. T. van Overbeek-van Gils
    • , G. H. Poortman
    • , S. T. Potgieter
    • , J. Potjewijd
    • , P. P. R. Rosias
    • , T. Sprong
    • , G. W. ten Tussher
    • , B. J. Thio
    • , G. A. Tramper-Stranders
    • , M. van Deuren
    • , H. van der Meer
    • , A. J. M. van Kuppevelt
    • , A. M. van Wermeskerken
    • , W. A. Verwijs
    • , T. F. W. Wolfs
    • , Philipp Agyeman
    • , Christoph Aebi
    • , Christoph Berger
    • , Eric Giannoni
    • , Martin Stocker
    • , Klara M Posfay-Barbe
    • , Ulrich Heininger
    • , Sara Bernhard-Stirnemann
    • , Anita Niederer-Loher
    • , Christian Kahlert
    • , Paul Hasters
    • , Christa Relly
    • , Walter Baer
    • , Stéphane Paulus
    • , Hannah Frederick
    • , Rebecca Jennings
    • , Joanne Johnston
    • , Rhian Kenwright
    • , Rachel Agbeko
    • , Kalifa Bojang
    • , Isatou Sarr
    • , Ngane Kebbeh
    • , Gibbi Sey
    • , Momodou Saidykhan
    • , Fatoumatta Cole
    • , Gilleh Thomas
    • , Martin Antonio
    • , Wolfgang Walcher
    • , Gotho Geishofer
    • , Daniela Klobassa
    • , Müller Martin
    • , Klaus Pfurtscheller
    • , Karl Reiter
    • , Siegfried Rödl
    • , Gerfried Zobel
    • , Bettina Zöhrer
    • , Bärbel Töpke
    • , Peter Fucik
    • , Markwart Gabriel
    • , Johann M. Penzien
    • , Gedeon Diab
    • , Robert Miething
    • , K. H. Deeg
    • , Jürg Hammer
    • , Ulrich Heininger
    • , Verena Varnholt
    • , Andreas Schmidt
    • , Lutz Bindl
    • , Ursula Sillaber
    • , Christian Huemer
    • , Primrose Meier
    • , G. Simic-Schleicher
    • , Markus Markart
    • , Eberhard Pfau
    • , Hans Broede
    • , Bernd Ausserer
    • , Hermann Kalhoff
    • , Volker Arpe
    • , Susanne Schweitzer-Krantz
    • , Johannes-Martin Kasper
    • , Kathrin Loranth
    • , Hans J. Bittrich
    • , Burkhard Simma
    • , Jens Klinge
    • , Michael Fedlmaier
    • , Nicola Weigand
    • , Egbert Herting
    • , Regina Grube
    • , Christoph Fusch
    • , Alois Gruber
    • , Ulf Schimmel
    • , Suzanne Knaufer-Schiefer
    • , Wolfgang Lässig
    • , Axel Hennenberger
    • , Axel von der Wense
    • , Roland Tillmann
    • , Jürgen Schwarick
    • , Friedrich C. Sitzmann
    • , Werner Streif
    • , Herbert Müller
    • , Peter Kurnik
    • , Peter Groneck
    • , Ute Weiss
    • , Helene Gröblacher-Roth
    • , Jürgen Bensch
    • , Reinhard Moser
    • , Rudolf Schwarz
    • , Kurt Lenz
    • , Thomas Hofmann
    • , Wolfgang Göpel
    • , Dietrich Schulz
    • , Thomas Berger
    • , Erwin Hauser
    • , Kai Martin Förster
    • , Jochen Peters
    • , T homas Nicolai
    • , Björn Kumlien
    • , Regina Beckmann
    • , Christiane Seitz
    • , D. Hüseman
    • , Roland Schürmann
    • , Van Hop Ta
    • , Eckart Weikmann
    • , W. Evert
    • , Jürgen Hautz
    • , Jürgen Seidenberg
    • , Lucia Wocko
    • , Petra Luigs
    • , Hans-Ludwig Reiter
    • , J. Quietzach
    • , Michael König
    • , Johanna Herrmann
    • , Horst Mitter
    • , Ekkehard Seidler
    • , Bernhard Maak
    • , Wolfgang Sperl
    • , Karl Zwiauer
    • , Manfred Meissl
    • , Reinhard Koch
    • , Manfred Cremer
    • , H. A. Breuer
    • , W. Görke
    • , Robert Nossal
    • , Walter Pernice
    • , Ralf Brangenberg
    • , Hans R. Salzer
    • , Hartmut Koch
    • , Gerhard Schaller
    • , Franz Paky
    • , Friedrich Straßer
    • , Franz Eitelberger
    • , D. Sontheimer
    • , Andreas Lischka
    • , Martina Kronberger
    • , Alfred Dilch
    • , Christian Scheibenpflug
    • , Robert Bruckner
    • , Klaus Mahler
    • , Klaus Runge
    • , Wolfgang Kunze
    •  & Peter Schermann

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