Gastroenterology articles within Nature Reviews Cardiology

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  • Review Article |

    In this Review, Bäckhed and colleagues summarize the evidence for gut microbiome alterations in cardiometabolic and cardiovascular diseases and the rationale and potential benefit motivating translational approaches to target the gut microbiota and its metabolites for prevention and treatment.

    • Rima Mohsen Chakaroun
    • , Lisa M. Olsson
    •  & Fredrik Bäckhed

  • Review Article |

    In this Review, the authors describe the mechanisms underlying lipopolysaccharide translocation from the gut to the systemic circulation and the ensuing low-grade endotoxaemia, discuss studies suggesting a role for low-grade endotoxaemia in atherothrombosis and cardiovascular complications, and highlight potential therapeutic strategies to improve gut permeability and eliminate low-grade endotoxaemia.

    • Francesco Violi
    • , Vittoria Cammisotto
    •  & Cristina Nocella

  • Research Highlight |

    Individuals with obesity have an increased prevalence of the Bacteroides 2 enterotype, which is associated with systemic inflammation and disease. However, statin therapy is associated with a reduced prevalence of this dysbiosis in individuals with obesity.

    • Gregory B. Lim

  • Research Highlight |

    A subset of T cells present in the small intestine modulate systemic metabolism and contribute to cardiovascular disease by limiting the bioavailability of the incretin hormone GLP1.

    • Irene Fernández-Ruiz

  • Review Article |

    Metabolites produced by gut microorganisms from dietary metabolism have been linked to the pathogenesis of heart failure, suggesting that the gut microbiome functions like an endocrine organ. In this Review, Tang and colleagues discuss the gut microbial metabolic pathways involved in heart failure and propose the gut microbiome as a therapeutic target.

    • W. H. Wilson Tang
    • , Daniel Y. Li
    •  & Stanley L. Hazen

  • News & Views |

    The gut microbiota has been associated with many different disorders, including cardiovascular diseases. A new study by Jie and colleagues is the first large case–control study to examine directly the enrichment of certain communities of gut bacteria in patients with atherosclerotic cardiovascular disease compared with control individuals.

    • William T. Barrington
    •  & Aldons J. Lusis

  • Review Article |

    A growing body of evidence supports the role of the gut microbiota in regulating blood pressure. In their Review, Marques and co-workers describe how the gut microbiota and its metabolites act on downstream cellular targets to influence the pathogenesis of hypertension. Novel strategies to modify the gut microbiota might present a new therapeutic avenue to improve health and prevent disease.

    • Francine Z. Marques
    • , Charles R. Mackay
    •  & David M. Kaye

  • Review Article |

    Microorganisms that populate the human body have been shown to be involved in metabolic and cardiovascular disorders, but the precise mechanisms are not completely understood. In this Review, Lindskog Jonsson and Bäckhed describe the different pathways by which the gut microbiota might affect the development of atherosclerosis.

    • Annika Lindskog Jonsson
    •  & Fredrik Bäckhed

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