Epigenetics in the nervous system articles within Nature

Featured

  • Article
    | Open Access

    A single-cell multiomics analysis of over 200,000 cells of the primary motor cortex of human, macaque, marmoset and mouse shows that divergence of transcription factor expression corresponds to species-specific epigenome landscapes, and conserved and divergent gene regulatory features are reflected in the evolution of the three-dimensional genome.

    • Nathan R. Zemke
    • , Ethan J. Armand
    •  & Bing Ren

  • Article
    | Open Access

    Methylome-based clustering and cross-modality integration with companion datasets from the BRAIN Initiative Cell Census Network enabled the construction of a 3D multi-omic genome atlas of the adult mouse brain featuring thousands of cell-type-specific profiles.

    • Hanqing Liu
    • , Qiurui Zeng
    •  & Joseph R. Ecker

  • Article
    | Open Access

    This study uses epi-retro-seq to link single-cell epigenomes and cell types to long-distance projections for neurons dissected from different regions projecting to different targets across the whole mouse brain.

    • Jingtian Zhou
    • , Zhuzhu Zhang
    •  & Edward M. Callaway

  • Article
    | Open Access

    Spatial-ATAC-seq—spatially resolved chromatin accessibility profiling of tissue sections using next-generation sequencing—delineated tissue-region-specific epigenetic landscapes in mouse embryos and identified gene regulators involved in the development of the central nervous system and the lymphoid tissue.

    • Yanxiang Deng
    • , Marek Bartosovic
    •  & Rong Fan

  • Article
    | Open Access

    A study maps neuronal genomic targets of oestrogen receptor-α and shows how they coordinate brain sexual differentiation, concluding that the genome remains responsive to hormonal changes after structural dimorphisms have been established.

    • B. Gegenhuber
    • , M. V. Wu
    •  & J. Tollkuhn

  • Article
    | Open Access

    A comprehensive survey of the epigenome from 45 regions of the mouse cortex, hippocampus, striatum, pallidum and olfactory areas using single-nucleus DNA methylation sequencing enables identification of 161 cell clusters with distinct locations and projection targets and provides insights into the regulatory landscape underlying neuronal diversity and spatial regulation.

    • Hanqing Liu
    • , Jingtian Zhou
    •  & Joseph R. Ecker

  • Article
    | Open Access

    Quantitative analysis of the methylation of mouse cortical neurons that project to different cortical and subcortical target regions provides insight into genetic mechanisms that contribute to differences in cell function.

    • Zhuzhu Zhang
    • , Jingtian Zhou
    •  & Edward M. Callaway

  • Letter
    | Open Access

    Analysis of transcriptional and epigenomic changes in the hippocampus of a mouse model of Alzheimer’s disease shows that immune function genes and regulatory regions are upregulated, whereas genes and regulatory regions involved in synaptic plasticity, learning and memory are downregulated; genetic variants associated with Alzheimer’s disease are only enriched in orthologues of upregulated immune regions, suggesting that dysregulation of immune processes may underlie Alzheimer’s disease predisposition.

    • Elizabeta Gjoneska
    • , Andreas R. Pfenning
    •  & Manolis Kellis

  • Letter |

    The authors identify a specific histone variant as a memory-suppressor that is initially reduced in expression within the hippocampus during memory formation; as a memory is consolidated to the cortex, reduced histone association with specific plasticity genes is observed, promoting stabilization of the memory.

    • Iva B. Zovkic
    • , Brynna S. Paulukaitis
    •  & J. David Sweatt

  • Letter |

    Rett syndrome is caused by mutations in MeCP2, and this study identifies a site on MeCP2, T308, whose phosphorylation is regulated by neuronal activity: phosphorylation of T308 blocks the interaction of MeCP2 with the NCoR co-repressor complex, suppressing MeCP2's ability to repress transcription, and mice carrying mutations of MeCP2 T308 show Rett-syndrome-related symptoms.

    • Daniel H. Ebert
    • , Harrison W. Gabel
    •  & Michael E. Greenberg

  • Comment |

    Trauma affects people differently. Epigenetics may be partly to blame, says Eric J. Nestler.

    • Eric J. Nestler

  • Letter |

    Histone deacetylase 2 is shown to suppress genes involved in cognitive function epigenetically, potentially opening the door to treatments for Alzheimer’s and other neurodegenerative diseases by developing HDAC2-selective inhibitors.

    • Johannes Gräff
    • , Damien Rei
    •  & Li-Huei Tsai

  • News Feature |

    Can epigenetics underlie the enduring effects of a mother's love? Lizzie Buchen investigates the criticisms of a landmark study and the controversial field to which it gave birth.

    • Lizzie Buchen

  • Editorial |

    • Magdalena Skipper
    • , Ursula Weiss
    •  & Noah Gray

Browse broader subjects

Browse narrower subjects

Browse Epigenetics in the nervous system across other nature.com journals