Epigenetics and behaviour articles within Nature

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  • Letter |

    The authors identify a specific histone variant as a memory-suppressor that is initially reduced in expression within the hippocampus during memory formation; as a memory is consolidated to the cortex, reduced histone association with specific plasticity genes is observed, promoting stabilization of the memory.

    • Iva B. Zovkic
    • , Brynna S. Paulukaitis
    •  & J. David Sweatt

  • Letter |

    Rett syndrome is caused by mutations in MeCP2, and this study identifies a site on MeCP2, T308, whose phosphorylation is regulated by neuronal activity: phosphorylation of T308 blocks the interaction of MeCP2 with the NCoR co-repressor complex, suppressing MeCP2's ability to repress transcription, and mice carrying mutations of MeCP2 T308 show Rett-syndrome-related symptoms.

    • Daniel H. Ebert
    • , Harrison W. Gabel
    •  & Michael E. Greenberg

  • News Feature |

    Can epigenetics underlie the enduring effects of a mother's love? Lizzie Buchen investigates the criticisms of a landmark study and the controversial field to which it gave birth.

    • Lizzie Buchen

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