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Lentiviral gene therapy vectors encoding VIP suppressed diabetes-related inflammation and augmented pancreatic beta-cell proliferation
- Fulya Erendor
- , Elif Ozgecan Sahin
- & Salih Sanlioglu
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Article |
Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy
- Bin Qu
- , Shijing Wu
- & Wei Li
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Original Article |
Repeated AAV-mediated gene transfer by serotype switching enables long-lasting therapeutic levels of hUgt1a1 enzyme in a mouse model of Crigler–Najjar Syndrome Type I
- L Bočkor
- , G Bortolussi
- & A F Muro
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Original Article |
An AAVrh10-CAG-CYP21-HA vector allows persistent correction of 21-hydroxylase deficiency in a Cyp21−/− mouse model
- M Perdomini
- , C Dos Santos
- & P Bougnères
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Original Article |
Adeno-associated virus-mediated expression of myostatin propeptide improves the growth of skeletal muscle and attenuates hyperglycemia in db/db mice
- J G Jiang
- , G F Shen
- & X Xiao
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Short Communication |
CRISPR-on system for the activation of the endogenous human INS gene
- C A Giménez
- , M Ielpi
- & F Pereyra-Bonnet
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Original Article |
IL-15/sIL-15Rα gene transfer induces weight loss and improves glucose homeostasis in obese mice
- H Sun
- , Y Ma
- & D Liu
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Original Article
| Open Access
Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus
- G Lu
- , X Teng
- & H Xiong
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Original Article |
Helper-dependent adenoviral vectors for liver-directed gene therapy of primary hyperoxaluria type 1
- R Castello
- , R Borzone
- & N Brunetti-Pierri
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Original Article
| Open Access
Mucopolysaccharidosis IIIB confers enhanced neonatal intracranial transduction by AAV8 but not by 5, 9 or rh10
- J A Gilkes
- , M D Bloom
- & C D Heldermon
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Original Article |
Neutralizing circulating ghrelin by expressing a growth hormone secretagogue receptor-based protein protects against high-fat diet-induced obesity in mice
- J Gagnon
- , L Zhu
- & Q Wang
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Original Article |
Adenoviral vector-mediated overexpression of osteoprotegerin accelerates osteointegration of titanium implants in ovariectomized rats
- G Yin
- , J Chen
- & E Luo
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Original Article |
Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector
- K Oka
- , C E Mullins
- & L Chan
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Original Article |
Expression of IL-2 in β cells by AAV8 gene transfer in pre-diabetic NOD mice prevents diabetes through activation of FoxP3-positive regulatory T cells
- R R Flores
- , L Zhou
- & P D Robbins
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Original Article
| Open Access
Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver
- P Maczuga
- , J Verheij
- & P Konstantinova
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Original Article |
Stable insulin-secreting ducts formed by reprogramming of cells in the liver using a three-gene cocktail and a PPAR agonist
- A Banga
- , L V Greder
- & J M W Slack
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Original Article |
Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice
- S Vasu
- , R C Moffett
- & P R Flatt
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Original Article |
Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance
- Y Ma
- & D Liu
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Original Article |
Matrix metalloproteinase-inspired suicidal treatments of diabetic ulcers with siRNA-decorated nanofibrous meshes
- H S Kim
- & H S Yoo
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Original Article |
Prolonged regulatable expression of EPO from an HSV vector using the LAP2 promoter element
- Z Wu
- , M Mata
- & D J Fink
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Original Article |
dsAAV8-mediated gene transfer and β-cell expression of IL-4 and β-cell growth factors are capable of reversing early-onset diabetes in NOD mice
- D F Gaddy
- , M J Riedel
- & P D Robbins
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Original Article |
Effective and safe gene-based delivery of GLP-1 using chitosan/plasmid-DNA therapeutic nanocomplexes in an animal model of type 2 diabetes
- M Jean
- , M Alameh
- & A Merzouki
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Original Article |
Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR−/− mice
- G Li
- , K C Biju
- & S Li
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Original Article |
Modulation of in utero total body irradiation induced newborn mouse growth retardation by maternal manganese superoxide dismutase-plasmid liposome (MnSOD-PL) gene therapy
- M W Epperly
- , T Smith
- & J S Greenberger
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Toward gene therapy of Laron syndrome
Finding my why
Pivotal role of leptin-hypothalamus signaling in the etiology of diabetes uncovered by gene therapy: a new therapeutic intervention?