Embryonic stem cells articles from across Nature Portfolio

Systematic infection of a human multi-organoid system shows that deficiency in the host factor CIART impairs SARS-CoV-2 infection through downregulation of the RXR pathway and subsequent impairment of fatty-acid synthesis.

Signal transduction and gene expression regulation via downstream transcription factors shape the early mammalian embryo. Here the authors show that Wnt/TCF7L1 transcriptional repressive activity is required for primitive endoderm lineage formation.

The authors present a protocol for the generation of human blastoids—structures morphologically and transcriptionally resembling complete blastocysts—from pluripotent stem cells and for their use in modeling implantation into hormonally stimulated endometrial cells.