Review Article |
Featured
-
-
News & Views |
Aspirin for asymptomatic atherosclerosis?
The ankle–brachial index (ABI) can be used to assess the risk of cardiovascular events. The AAA trial aimed to determine whether low-dose aspirin was of net benefit among apparently healthy people with an ABI ≤0.95. The largely negative findings of this study raise important mechanistic and practical questions.
- Carlo Patrono
- & Colin Baigent
-
Review Article |
New developments in atrial antiarrhythmic drug therapy
Atrial fibrillation (AF) has multifactorial intracardiac and extracardiac causes. Current development of anti-AF agents is focused on modulation of ion channel activity as well as on upstream therapies that reduce structural substrates. In this Review, Burashnikov and Antzelevitch examine new and emerging pharmacological approaches to rhythm control in patients with AF and summarize the available data on these drugs.
- Alexander Burashnikov
- & Charles Antzelevitch