Consanguinity

Consanguinity is the property of having a recent common ancestor with another individual. The genetic distance between two individuals can be expressed in meioses (the number of times the shared genome is halved by the generation of ova or sperm) or by the coefficient of relationship (r).

Latest Research and Reviews

  • Research
    | Open Access

    • Sayed AbdulAzeez
    • , Nourah H. Al Qahtani
    • , Noor B. Almandil
    • , Amani M. Al-Amodi
    • , Sumayh A. Aldakeel
    • , Neda Z. Ghanem
    • , Deem N. Alkuroud
    • , Ameen AlTurki
    • , Quds Abdulhakeem AlQattan
    • , Abdulrahman Alghamdi
    • , Norah Fahad Alhur
    • , Hatoon Ahmed Al Taifi
    • , Halah Egal Aljofi
    • , B. Rabindran Jermy
    • , Vinoth Raman
    • , Antonino Giambona
    • , Aurelio Maggio
    •  & J. Francis Borgio
  • Research
    | Open Access

    Inbreeding depression has been observed in many different species, but in humans a systematic analysis has been difficult so far. Here, analysing more than 1.3 million individuals, the authors show that a genomic inbreeding coefficient (FROH) is associated with disadvantageous outcomes in 32 out of 100 traits tested.

    • David W Clark
    • , Yukinori Okada
    • , Kristjan H S Moore
    • , Dan Mason
    • , Nicola Pirastu
    • , Ilaria Gandin
    • , Hannele Mattsson
    • , Catriona L K Barnes
    • , Kuang Lin
    • , Jing Hua Zhao
    • , Patrick Deelen
    • , Rebecca Rohde
    • , Claudia Schurmann
    • , Xiuqing Guo
    • , Franco Giulianini
    • , Weihua Zhang
    • , Carolina Medina-Gomez
    • , Robert Karlsson
    • , Yanchun Bao
    • , Traci M Bartz
    • , Clemens Baumbach
    • , Ginevra Biino
    • , Matthew J Bixley
    • , Marco Brumat
    • , Jin-Fang Chai
    • , Tanguy Corre
    • , Diana L Cousminer
    • , Annelot M Dekker
    • , David A Eccles
    • , Kristel R van Eijk
    • , Christian Fuchsberger
    • , He Gao
    • , Marine Germain
    • , Scott D Gordon
    • , Hugoline G de Haan
    • , Sarah E Harris
    • , Edith Hofer
    • , Alicia Huerta-Chagoya
    • , Catherine Igartua
    • , Iris E Jansen
    • , Yucheng Jia
    • , Tim Kacprowski
    • , Torgny Karlsson
    • , Marcus E Kleber
    • , Shengchao Alfred Li
    • , Ruifang Li-Gao
    • , Anubha Mahajan
    • , Koichi Matsuda
    • , Karina Meidtner
    • , Weihua Meng
    • , May E Montasser
    • , Peter J van der Most
    • , Matthias Munz
    • , Teresa Nutile
    • , Teemu Palviainen
    • , Gauri Prasad
    • , Rashmi B Prasad
    • , Tallapragada Divya Sri Priyanka
    • , Federica Rizzi
    • , Erika Salvi
    • , Bishwa R Sapkota
    • , Daniel Shriner
    • , Line Skotte
    • , Melissa C Smart
    • , Albert Vernon Smith
    • , Ashley van der Spek
    • , Cassandra N Spracklen
    • , Rona J Strawbridge
    • , Salman M Tajuddin
    • , Stella Trompet
    • , Constance Turman
    • , Niek Verweij
    • , Clara Viberti
    • , Lihua Wang
    • , Helen R Warren
    • , Robyn E Wootton
    • , Lisa R Yanek
    • , Jie Yao
    • , Noha A Yousri
    • , Wei Zhao
    • , Adebowale A Adeyemo
    • , Saima Afaq
    • , Carlos Alberto Aguilar-Salinas
    • , Masato Akiyama
    • , Matthew L Albert
    • , Matthew A Allison
    • , Maris Alver
    • , Tin Aung
    • , Fereidoun Azizi
    • , Amy R Bentley
    • , Heiner Boeing
    • , Eric Boerwinkle
    • , Judith B Borja
    • , Gert J de Borst
    • , Erwin P Bottinger
    • , Linda Broer
    • , Harry Campbell
    • , Stephen Chanock
    • , Miao-Li Chee
    • , Guanjie Chen
    • , Yii-Der I Chen
    • , Zhengming Chen
    • , Yen-Feng Chiu
    • , Massimiliano Cocca
    • , Francis S Collins
    • , Maria Pina Concas
    • , Janie Corley
    • , Giovanni Cugliari
    • , Rob M van Dam
    • , Anna Damulina
    • , Maryam S Daneshpour
    • , Felix R Day
    • , Graciela E Delgado
    • , Klodian Dhana
    • , Alexander S F Doney
    • , Marcus Dörr
    • , Ayo P Doumatey
    • , Nduna Dzimiri
    • , S Sunna Ebenesersdóttir
    • , Joshua Elliott
    • , Paul Elliott
    • , Ralf Ewert
    • , Janine F Felix
    • , Krista Fischer
    • , Barry I Freedman
    • , Giorgia Girotto
    • , Anuj Goel
    • , Martin Gögele
    • , Mark O Goodarzi
    • , Mariaelisa Graff
    • , Einat Granot-Hershkovitz
    • , Francine Grodstein
    • , Simonetta Guarrera
    • , Daniel F Gudbjartsson
    • , Kamran Guity
    • , Bjarni Gunnarsson
    • , Yu Guo
    • , Saskia P Hagenaars
    • , Christopher A Haiman
    • , Avner Halevy
    • , Tamara B Harris
    • , Mehdi Hedayati
    • , David A van Heel
    • , Makoto Hirata
    • , Imo Höfer
    • , Chao Agnes Hsiung
    • , Jinyan Huang
    • , Yi-Jen Hung
    • , M Arfan Ikram
    • , Anuradha Jagadeesan
    • , Pekka Jousilahti
    • , Yoichiro Kamatani
    • , Masahiro Kanai
    • , Nicola D Kerrison
    • , Thorsten Kessler
    • , Kay-Tee Khaw
    • , Chiea Chuen Khor
    • , Dominique P V de Kleijn
    • , Woon-Puay Koh
    • , Ivana Kolcic
    • , Peter Kraft
    • , Bernhard K Krämer
    • , Zoltán Kutalik
    • , Johanna Kuusisto
    • , Claudia Langenberg
    • , Lenore J Launer
    • , Deborah A Lawlor
    • , I-Te Lee
    • , Wen-Jane Lee
    • , Markus M Lerch
    • , Liming Li
    • , Jianjun Liu
    • , Marie Loh
    • , Stephanie J London
    • , Stephanie Loomis
    • , Yingchang Lu
    • , Jian’an Luan
    • , Reedik Mägi
    • , Ani W Manichaikul
    • , Paolo Manunta
    • , Gísli Másson
    • , Nana Matoba
    • , Xue W Mei
    • , Christa Meisinger
    • , Thomas Meitinger
    • , Massimo Mezzavilla
    • , Lili Milani
    • , Iona Y Millwood
    • , Yukihide Momozawa
    • , Amy Moore
    • , Pierre-Emmanuel Morange
    • , Hortensia Moreno-Macías
    • , Trevor A Mori
    • , Alanna C Morrison
    • , Taulant Muka
    • , Yoshinori Murakami
    • , Alison D Murray
    • , Renée de Mutsert
    • , Josyf C Mychaleckyj
    • , Mike A Nalls
    • , Matthias Nauck
    • , Matt J Neville
    • , Ilja M Nolte
    • , Ken K Ong
    • , Lorena Orozco
    • , Sandosh Padmanabhan
    • , Gunnar Pálsson
    • , James S Pankow
    • , Cristian Pattaro
    • , Alison Pattie
    • , Ozren Polasek
    • , Neil Poulter
    • , Peter P Pramstaller
    • , Lluis Quintana-Murci
    • , Katri Räikkönen
    • , Sarju Ralhan
    • , Dabeeru C Rao
    • , Wouter van Rheenen
    • , Stephen S Rich
    • , Paul M Ridker
    • , Cornelius A Rietveld
    • , Antonietta Robino
    • , Frank J A van Rooij
    • , Daniela Ruggiero
    • , Yasaman Saba
    • , Charumathi Sabanayagam
    • , Maria Sabater-Lleal
    • , Cinzia Felicita Sala
    • , Veikko Salomaa
    • , Kevin Sandow
    • , Helena Schmidt
    • , Laura J Scott
    • , William R Scott
    • , Bahareh Sedaghati-Khayat
    • , Bengt Sennblad
    • , Jessica van Setten
    • , Peter J Sever
    • , Wayne H-H Sheu
    • , Yuan Shi
    • , Smeeta Shrestha
    • , Sharvari Rahul Shukla
    • , Jon K Sigurdsson
    • , Timo Tonis Sikka
    • , Jai Rup Singh
    • , Blair H Smith
    • , Alena Stančáková
    • , Alice Stanton
    • , John M Starr
    • , Lilja Stefansdottir
    • , Leon Straker
    • , Patrick Sulem
    • , Gardar Sveinbjornsson
    • , Morris A Swertz
    • , Adele M Taylor
    • , Kent D Taylor
    • , Natalie Terzikhan
    • , Yih-Chung Tham
    • , Gudmar Thorleifsson
    • , Unnur Thorsteinsdottir
    • , Annika Tillander
    • , Russell P Tracy
    • , Teresa Tusié-Luna
    • , Ioanna Tzoulaki
    • , Simona Vaccargiu
    • , Jagadish Vangipurapu
    • , Jan H Veldink
    • , Veronique Vitart
    • , Uwe Völker
    • , Eero Vuoksimaa
    • , Salma M Wakil
    • , Melanie Waldenberger
    • , Gurpreet S Wander
    • , Ya Xing Wang
    • , Nicholas J Wareham
    • , Sarah Wild
    • , Chittaranjan S Yajnik
    • , Jian-Min Yuan
    • , Lingyao Zeng
    • , Liang Zhang
    • , Jie Zhou
    • , Najaf Amin
    • , Folkert W Asselbergs
    • , Stephan J L Bakker
    • , Diane M Becker
    • , Benjamin Lehne
    • , David A Bennett
    • , Leonard H van den Berg
    • , Sonja I Berndt
    • , Dwaipayan Bharadwaj
    • , Lawrence F Bielak
    • , Murielle Bochud
    • , Mike Boehnke
    • , Claude Bouchard
    • , Jonathan P Bradfield
    • , Jennifer A Brody
    • , Archie Campbell
    • , Shai Carmi
    • , Mark J Caulfield
    • , David Cesarini
    • , John C Chambers
    • , Giriraj Ratan Chandak
    • , Ching-Yu Cheng
    • , Marina Ciullo
    • , Marilyn Cornelis
    • , Daniele Cusi
    • , George Davey Smith
    • , Ian J Deary
    • , Rajkumar Dorajoo
    • , Cornelia M van Duijn
    • , David Ellinghaus
    • , Jeanette Erdmann
    • , Johan G Eriksson
    • , Evangelos Evangelou
    • , Michele K Evans
    • , Jessica D Faul
    • , Bjarke Feenstra
    • , Mary Feitosa
    • , Sylvain Foisy
    • , Andre Franke
    • , Yechiel Friedlander
    • , Paolo Gasparini
    • , Christian Gieger
    • , Clicerio Gonzalez
    • , Philippe Goyette
    • , Struan F A Grant
    • , Lyn R Griffiths
    • , Leif Groop
    • , Vilmundur Gudnason
    • , Ulf Gyllensten
    • , Hakon Hakonarson
    • , Anders Hamsten
    • , Pim van der Harst
    • , Chew-Kiat Heng
    • , Andrew A Hicks
    • , Hagit Hochner
    • , Heikki Huikuri
    • , Steven C Hunt
    • , Vincent W V Jaddoe
    • , Philip L De Jager
    • , Magnus Johannesson
    • , Åsa Johansson
    • , Jost B Jonas
    • , J Wouter Jukema
    • , Juhani Junttila
    • , Jaakko Kaprio
    • , Sharon L. R. Kardia
    • , Fredrik Karpe
    • , Meena Kumari
    • , Markku Laakso
    • , Sander W van der Laan
    • , Jari Lahti
    • , Matthias Laudes
    • , Rodney A Lea
    • , Wolfgang Lieb
    • , Thomas Lumley
    • , Nicholas G Martin
    • , Winfried März
    • , Giuseppe Matullo
    • , Mark I McCarthy
    • , Sarah E Medland
    • , Tony R Merriman
    • , Andres Metspalu
    • , Brian F Meyer
    • , Karen L Mohlke
    • , Grant W Montgomery
    • , Dennis Mook-Kanamori
    • , Patricia B Munroe
    • , Kari E North
    • , Dale R Nyholt
    • , Jeffery R O’connell
    • , Carole Ober
    • , Albertine J Oldehinkel
    • , Walter Palmas
    • , Colin Palmer
    • , Gerard G Pasterkamp
    • , Etienne Patin
    • , Craig E Pennell
    • , Louis Perusse
    • , Patricia A Peyser
    • , Mario Pirastu
    • , Tinca J. C. Polderman
    • , David J Porteous
    • , Danielle Posthuma
    • , Bruce M Psaty
    • , John D Rioux
    • , Fernando Rivadeneira
    • , Charles Rotimi
    • , Jerome I Rotter
    • , Igor Rudan
    • , Hester M Den Ruijter
    • , Dharambir K Sanghera
    • , Naveed Sattar
    • , Reinhold Schmidt
    • , Matthias B Schulze
    • , Heribert Schunkert
    • , Robert A Scott
    • , Alan R Shuldiner
    • , Xueling Sim
    • , Neil Small
    • , Jennifer A Smith
    • , Nona Sotoodehnia
    • , E-Shyong Tai
    • , Alexander Teumer
    • , Nicholas J Timpson
    • , Daniela Toniolo
    • , David-Alexandre Tregouet
    • , Tiinamaija Tuomi
    • , Peter Vollenweider
    • , Carol A Wang
    • , David R Weir
    • , John B Whitfield
    • , Cisca Wijmenga
    • , Tien-Yin Wong
    • , John Wright
    • , Jingyun Yang
    • , Lei Yu
    • , Babette S Zemel
    • , Alan B Zonderman
    • , Markus Perola
    • , Patrik K. E. Magnusson
    • , André G Uitterlinden
    • , Jaspal S Kooner
    • , Daniel I Chasman
    • , Ruth J. F. Loos
    • , Nora Franceschini
    • , Lude Franke
    • , Chris S Haley
    • , Caroline Hayward
    • , Robin G Walters
    • , John R. B. Perry
    • , Tōnu Esko
    • , Agnar Helgason
    • , Kari Stefansson
    • , Peter K Joshi
    • , Michiaki Kubo
    •  & James F Wilson
  • Research
    | Open Access

    Mating between first or second-degree relatives is prohibited in most countries, yet it occurs and is under-studied. Here, Yengo et al. use large runs of homozygosity from the UK Biobank resource to provide DNA-based quantification of extreme inbreeding and its consequence for health and other complex traits.

    • Loic Yengo
    • , Naomi R. Wray
    •  & Peter M. Visscher