Cellular signalling networks articles within Nature

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  • Article
    | Open Access

    An atlas of the substrate specificities for the human tyrosine kinome reveals diversity of motif specificities and enables identification of kinase–substrate relationships and kinase regulation in phosphoproteomics experiments.

    • Tomer M. Yaron-Barir
    • , Brian A. Joughin
    •  & Jared L. Johnson

  • Article
    | Open Access

    Studies in mice show that effector T regulatory cells in the gut are most functional in the lamina propria, but this homeostatic niche is disrupted in inflammation, suggesting a spatial mechanism of tolerance to commensal microorganisms.

    • Yisu Gu
    • , Raquel Bartolomé-Casado
    •  & Fiona Powrie

  • Article
    | Open Access

    Combining single-cell RNA-sequencing with high-resolution multiplexed error-robust fluorescence in situ hybridization reveals in detail the cellular interactions and specialization of cardiac cell types that form and remodel the human heart.

    • Elie N. Farah
    • , Robert K. Hu
    •  & Neil C. Chi

  • Article
    | Open Access

    A high-resolution kidney cellular atlas of 51 main cell types, including rare and previously undescribed cell populations, represents a comprehensive benchmark of cellular states, neighbourhoods, outcome-associated signatures and publicly available interactive visualizations.

    • Blue B. Lake
    • , Rajasree Menon
    •  & Sanjay Jain

  • Article
    | Open Access

    We uncover the mechanism underlying the restriction point phenomenon, suggest a role for cyclin-dependent kinase 4 and 6 activity in S and G2 phases, and explain the behaviour of cells following loss of mitogen signalling.

    • James A. Cornwell
    • , Adrijana Crncec
    •  & Steven D. Cappell

  • Article
    | Open Access

    Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by negative selectivity

    • Jared L. Johnson
    • , Tomer M. Yaron
    •  & Lewis C. Cantley

  • Article
    | Open Access

    Cells from embryonic, fetal, paediatric and adult human intestinal tissue are analysed at different locations along the intestinal tract to construct a single-cell atlas of the developing and adult human intestinal tract, encompassing all cell lineages.

    • Rasa Elmentaite
    • , Natsuhiko Kumasaka
    •  & Sarah A. Teichmann

  • Article |

    Lung samples collected soon after death from COVID-19 are used to provide a single-cell atlas of SARS-CoV-2 infection and the ensuing molecular changes.

    • Johannes C. Melms
    • , Jana Biermann
    •  & Benjamin Izar

  • Article |

    A systems-level map of the Arabidopsis hormone signalling network, comprising more than 2,000 binary protein–protein interactions, reveals hundreds of interpathway contact points, many of which mediate crosstalk between different hormone pathways.

    • Melina Altmann
    • , Stefan Altmann
    •  & Pascal Falter-Braun

  • Letter |

    For synthetic biologists' creativity to be unleashed, basic circuits must become truly interchangeable, that is, modular and scalable. This study, one of two linked papers, has harnessed yeast pheromone communication to achieve complex computation through communication between individual cells performing simple logic functions. Such extracellular 'chemical wiring' is one promising way to get around intracellular noise when building more complex genetic circuitry.

    • Sergi Regot
    • , Javier Macia
    •  & Ricard Solé

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