Cell adhesion articles from across Nature Portfolio

Cell adhesion is the process by which cells form contacts with each other or with their substratum through specialized protein complexes. Intercellular adhesion can be mediated by adherens junctions, tight junctions and desmosomes, whereas cells can interact with extracellular matrix molecules through focal adhesions.

Latest Research and Reviews

Research
05 June 2023 | Open Access

Downregulation of extraembryonic tension controls body axis formation in avian embryos

Extraembryonic tissues provide structural support in addition to signaling inputs. Here they show that extraembryonic structures regulate the mechanical environment of the developing chicken embryo, wherein weakening of the vitelline membrane permits tissue movements that form the body axis.
- Daniele Kunz
- , Anfu Wang
- & Fengzhu Xiong
Nature Communications 14, 3266
Research
24 May 2023 | Open Access

Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction

Cleft lip and palate is a common birth defect thought to involve both genetic and environmental components in its etiology. Here they identify a mechanism involving inflammation and E-cadherin mutations that reduces neural crest migration, leading to craniofacial defects.
- Lucas Alvizi
- , Diogo Nani
- & Roberto Mayor
Nature Communications 14, 2868
Research
22 May 2023 | Open Access

Chemo-mechanical diffusion waves explain collective dynamics of immune cell podosomes

Dendritic cells can utilize the dynamics of podosomes to probe their microenvironment. Here, the authors propose a chemo-mechanical model for the height oscillations of individual podosomes and the collective wave dynamics in a podosome cluster.
- Ze Gong
- , Koen van den Dries
- & Vivek B. Shenoy
Nature Communications 14, 2902
Research
16 May 2023 | Open Access

A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly

YAP signaling has been established as a mechanotransductive pathway in multiple contexts, but its developmental roles are still being explored. Here they show that YAP signaling sustains intracellular tension to direct cell migration during embryonic axis assembly.
- Ana Sousa-Ortega
- , Javier Vázquez-Marín
- & Juan R. Martínez-Morales
Nature Communications 14, 2804
Research
12 May 2023 | Open Access

Polarity signaling balances epithelial contractility and mechanical resistance
- Matthias Rübsam
- , Robin Püllen
- & Carien M. Niessen
Scientific Reports 13, 7743
Research | 12 May 2023

Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway
- Pan Wu
- , Xiangchan Hou
- & Bo Xiang
Cell Death & Differentiation, 1-16

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News and Comment

News & Views | 16 February 2023

Niche tension controls exosome production

Extracellular matrix (ECM) stiffening is a hallmark of cancer aggressiveness. Diverse ECM environments can alter the number and cargo of small extracellular vesicles (sEVs). Wu et al. now delineate a pathway from ECM stiffness to FAK/PI3K/Akt signalling and Rab8-induced sEV secretion, promoting cancer growth.
- Toni Renee Dawson
- & Alissa Margaret Weaver
Nature Cell Biology 25, 377-378
Research Highlights | 07 February 2023

Ageing matrix makes chondrocytes feel old

Age-related stiffening of the extracellular matrix in cartilage promotes chondrocyte ageing in an epigenetically controlled process involving repression of the longevity protein α-Klotho.
- Jessica McHugh
Nature Reviews Rheumatology 19, 127
Research Highlights | 20 January 2023

Infusible extracellular matrix

An article in Nature Biomedical Engineering reports an intravenously injectable extracellular matrix biomaterial that can target and seal injured tissue by binding to leaky microvasculature.
- Christine-Maria Horejs
Nature Reviews Bioengineering 1, 86
News & Views | 14 November 2022

VEGF signaling and cell adhesion interplay controls sinusoidal and lymphatic growth

Loss of VEGF-C or VEGFR3 function or gain of VE-cadherin function causes identical defects in sinusoidal and lymphatic growth, resulting in anemia and lymphedema. Mechanistically, VEGF-C drives VE-cadherin phosphorylation and endocytosis whereas VE-cadherin prevents VEGFR3 internalization and downstream growth factor signaling. In the absence of VEGFR3, reducing VE-cadherin levels rescues vascular growth by potentiating VEGF-C–VEGFR2 signaling.

Nature Cardiovascular Research 1, 986-987
Research Highlights | 26 August 2022

NCKs are essential to podocyte–GBM interactions
- Monica Wang
Nature Reviews Nephrology 18, 605
News & Views | 24 August 2022

In search of a softer environment

By maximizing cell–substrate force transmission, cancer cells can migrate towards either stiffer or softer substrate regions.
- Amy E. M. Beedle
- & Pere Roca-Cusachs
Nature Materials 21, 995-996

All News & Comment

Cell adhesion articles from across Nature Portfolio

Latest Research and Reviews

Downregulation of extraembryonic tension controls body axis formation in avian embryos

Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction

Chemo-mechanical diffusion waves explain collective dynamics of immune cell podosomes

A Yap-dependent mechanoregulatory program sustains cell migration for embryo axis assembly

Polarity signaling balances epithelial contractility and mechanical resistance

Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway

News and Comment

Niche tension controls exosome production

Ageing matrix makes chondrocytes feel old

Infusible extracellular matrix

VEGF signaling and cell adhesion interplay controls sinusoidal and lymphatic growth

NCKs are essential to podocyte–GBM interactions

In search of a softer environment

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Cell adhesion articles from across Nature Portfolio

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