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Aortic aneurysm

Platelet ceramides drive thrombo-inflammation in aortic aneurysm formation

Nature Cardiovascular Research volume 2, pages 1112–1114 (2023)Cite this article

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Effective pharmacological treatment options for abdominal aortic aneurysm (AAA) are missing. A study by Zhang et al. suggests that targeting the thrombo-inflammatory activity of platelets by blocking the intracellular accumulation of ceramides might limit AAA progression while not affecting hemostatic platelet function.

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Fig. 1: Thrombo-inflammation drives in aortic aneurysm formation.

References

  1. Golledge, J. Nat. Rev. Cardiol. 16, 225–242 (2019).

    Article  PubMed  Google Scholar 

  2. Cameron, S. J. et al. Blood 132, 2619–2628 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Owens, A. P. et al. Arterioscler. Thromb. Vasc. Biol. 35, 2032–2041 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Lindholt, J. S. et al. Vasc. Endovascular. Surg. 42, 329–334 (2008).

    Article  PubMed  Google Scholar 

  5. Thompson, A. et al. J. Vasc. Surg. 52, 55–61 (2010).

    Article  PubMed  Google Scholar 

  6. Stoll, G. & Nieswandt, B. Nat. Rev. Neurol. 15, 473–481 (2019).

    Article  CAS  PubMed  Google Scholar 

  7. Kleinschnitz, C. et al. Circulation 115, 2323–2330 (2007).

    Article  CAS  PubMed  Google Scholar 

  8. Nieswandt, B. et al. J. Physiol. 589, 4115–4123 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zhang, X. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00364-1 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Choi, R. H. et al. Nat. Rev. Cardiol. 18, 701–711 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We thank V. Göb and S. Beck for critical reading of the manuscript, and S. Beck for help with preparation of the figure. The work in our laboratory is continuously funded by the Deutsche Forschungsgemeinschaft (DFG; German Research Foundation), project number 374031971–TRR 240 and project number 453989101–SFB1525.

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Authors and Affiliations

  1. Institute of Experimental Biomedicine I, University Hospital Würzburg, Würzburg, Germany

    Bernhard Nieswandt & Timo Vögtle

  2. Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Würzburg, Germany

    Bernhard Nieswandt & Timo Vögtle

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  1. Bernhard Nieswandt
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  2. Timo Vögtle
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Correspondence to Bernhard Nieswandt.

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The authors declare no competing interests.

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Nieswandt, B., Vögtle, T. Platelet ceramides drive thrombo-inflammation in aortic aneurysm formation. Nat Cardiovasc Res 2, 1112–1114 (2023). https://doi.org/10.1038/s44161-023-00374-z

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