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Are genetically modified protozoa eligible for ATMP status? Concerning the legal categorization of an oncolytic protozoan drug candidate
- Mathieu Guerriaud
- , Cyril Poupet
- & Nathalie Moiré
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Article
| Open AccessSuccesses and challenges in clinical gene therapy
- Donald B. Kohn
- , Yvonne Y. Chen
- & Melissa J. Spencer
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p53 dry gene powder enhances anti-cancer effects of chemotherapy against malignant pleural mesothelioma
- Naomi Muramatsu
- , Misa Ichikawa
- & Hirokazu Okamoto
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Article
| Open Access
RapaCaspase-9-based suicide gene applied to the safety of IL-1RAP CAR-T cells
- Lucie Bouquet
- , Elodie Bôle-Richard
- & Marina Deschamps
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Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome system
- Shinta Tominaga
- , Toshiyasu Ojima
- & Hiroki Yamaue
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Brief Communication
| Open Access
Glyco-binding domain chimeric antigen receptors as a new option for cancer immunotherapy
- Anna-Katharina Franke
- , Charlotte Wessolowski
- & Kerstin Cornils
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Article
| Open Access
HIV- 1 lentivirus tethering to the genome is associated with transcription factor binding sites found in genes that favour virus survival
- Saqlain Suleman
- , Annette Payne
- & Michael Themis
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Exosomal PD-L1 confers chemoresistance and promotes tumorigenic properties in esophageal cancer cells via upregulating STAT3/miR-21
- Haojie Wang
- , Yijun Qi
- & Gaofeng Liang
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Article
| Open Access
Exon skipping induced by CRISPR-directed gene editing regulates the response to chemotherapy in non-small cell lung carcinoma cells
- Kelly Banas
- , Shirin Modarai
- & Eric B. Kmiec
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Perspective |
Equitable access to cell and gene therapies in South Africa: opportunities and hurdles
- Candice Laverne Hendricks
- , Marco Alessandrini
- & Michael Sean Pepper
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E3 ubiquitin ligase SMURF2 prevents colorectal cancer by reducing the stability of the YY1 protein and inhibiting the SENP1/c-myc axis
- Qianfu Gao
- , Shanchao Wang
- & Zeyan Zhang
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Thrombopoietin-based CAR-T cells demonstrate in vitro and in vivo cytotoxicity to MPL positive acute myelogenous leukemia and hematopoietic stem cells
- Jaquelyn T. Zoine
- , Chengyu Prince
- & Shanmuganathan Chandrakasan
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Brief Communication |
Suppression of bone metastatic castration-resistant prostate cancer cell growth by a suicide gene delivered by JC polyomavirus-like particles
- Cheng-Huang Shen
- , Mien-Chun Lin
- & Meilin Wang
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rAAV-based and intraprostatically delivered miR-34a therapeutics for efficient inhibition of prostate cancer progression
- Jianzhong Ai
- , Jia Li
- & Guangping Gao
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Adjuvant properties of IFN-γ and GM-CSF in the scFv6.C4 DNA vaccine against CEA-expressing tumors
- Bianca Ferrarini Zanetti
- , Camila Pontes Ferreira
- & Sang Won Han
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Chitosan-coated Zn-metal-organic framework nanocomposites for effective targeted delivery of LNA-antisense miR-224 to colon tumor: in vitro studies
- Negin Mokri
- , Zahra Sepehri
- & Mehrdad Hashemi
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Distinct functions of CAR-T cells possessing a dectin-1 intracellular signaling domain
- Xiao Liang
- , Yong Huang
- & Wei Wang
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Membrane-bound MMP-14 protease-activatable adeno-associated viral vectors for gene delivery to pancreatic tumors
- Susan S. Butler
- , Kenjiro Date
- & Junghae Suh
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Article
| Open Access
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma
- Sabrina Prommersberger
- , Michael Reiser
- & Zoltán Ivics
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Review Article
| Open Access
Current status and perspective of CAR-T and CAR-NK cell therapy trials in Germany
- Nawid Albinger
- , Jessica Hartmann
- & Evelyn Ullrich
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Review Article |
Effects of oncolytic viruses and viral vectors on immunity in glioblastoma
- Penghao Liu
- , Yaning Wang
- & Yu Wang
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Article |
Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3
- Xiao-Yu Zhang
- , Hai-Wen Zhuang
- & Jin Dou
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Review Article |
Gene therapy and gene correction: targets, progress, and challenges for treating human diseases
- Matthew R. Cring
- & Val C. Sheffield
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Brief Communication |
Easy and robust electrotransfection protocol for efficient ectopic gene expression and genome editing in human B cells
- Reynand Jay Canoy
- , Franck André
- & Diego Germini
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Article |
Role and the molecular mechanism of lncRNA PTENP1 in regulating the proliferation and invasion of cervical cancer cells
- Chengping Wu
- , Fang Wang
- & Li Tan
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Silencing of long non-coding RNA FOXD2-AS1 inhibits the progression of gallbladder cancer by mediating methylation of MLH1
- Jun Gao
- , Chao Dai
- & Fan Zhou
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Article |
LncRNA SNHG16 promotes colorectal cancer cell proliferation, migration, and epithelial–mesenchymal transition through miR-124-3p/MCP-1
- Zhi-Yuan Chen
- , Xiang-Yang Wang
- & Ya Peng
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Article |
miR-503-5p inhibits colon cancer tumorigenesis, angiogenesis, and lymphangiogenesis by directly downregulating VEGF-A
- Linlin Wei
- , Chaonan Sun
- & Shichen Sun
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Review Article |
An overview of development in gene therapeutics in China
- Dawei Wang
- , Kang Wang
- & Yujia Cai
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Comment |
scFv6.C4 DNA vaccine with fragment C of tetanus toxin increases protective immunity against CEA-expressing tumor
- Anjali Geethadevi
- , Kapilesh Jadhav
- & Deepak Parashar
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Article
| Open Access
Optimization of oncolytic effect of Newcastle disease virus Clone30 by selecting sensitive tumor host and constructing more oncolytic viruses
- Tianyan Liu
- , Yu Zhang
- & Deshan Li
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Article |
Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509-3p/PDGFRA axis
- Wei Li
- , Yufeng He
- & Po Yang
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AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo
- Ling Yin
- , Geoffrey D. Keeler
- & Arun Srivastava
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Particulate mediators of the bystander effect linked to suicide and interferon-β transgene expression in melanoma cells
- Lucrecia Agnetti
- , Chiara Fondello
- & Liliana M. E. Finocchiaro
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LncRNA OIP5-AS1 interacts with miR-363-3p to contribute to hepatocellular carcinoma progression through up-regulation of SOX4
- Jianchu Wang
- , Qianli Tang
- & Jian Pu
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Cancer gene therapy by NF-κB-activated cancer cell-specific expression of CRISPR/Cas9 targeting telomeres
- Wei Dai
- , Jian Wu
- & Jinke Wang
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Hsa_circ_0000285 functions as a competitive endogenous RNA to promote osteosarcoma progression by sponging hsa-miRNA-599
- Zhicai Zhang
- , Feifei Pu
- & Zengwu Shao
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RETRACTED ARTICLE: Long noncoding RNA RBMS3-AS3 acts as a microRNA-4534 sponge to inhibit the progression of prostate cancer by upregulating VASH1
- Zhenming Jiang
- , Yuxi Zhang
- & Dong Chen
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Inferring novel genes related to oral cancer with a network embedding method and one-class learning algorithms
- Lei Chen
- , Yu-Hang Zhang
- & Yu-Dong Cai
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Article |
Bicistronic transfer of CDKN2A and p53 culminates in collaborative killing of human lung cancer cells in vitro and in vivo
- Juliana G. Xande
- , Ana P. Dias
- & Eugenia Costanzi-Strauss
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Article |
Inferring novel genes related to colorectal cancer via random walk with restart algorithm
- Sheng Lu
- , Zheng-Gang Zhu
- & Wen-Cong Lu
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Brief Communication |
Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors
- Ren-Yuan Bai
- , Dominic Esposito
- & Verena Staedtke
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Article |
Combination of cabazitaxel and p53 gene therapy abolishes prostate carcinoma tumor growth
- Rodrigo Esaki Tamura
- , Marlous G. Lana
- & Bryan E. Strauss
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Article |
A novel xenograft mouse model for testing approaches targeting human kappa light-chain diseases
- Xun Ma
- , Ping Zhou
- & Raymond L. Comenzo
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A novel approach for assessment of prostate cancer aggressiveness using survivin-driven tumour-activatable minicircles
- TianDuo Wang
- , Yuanxin Chen
- & John. A. Ronald
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Article |
Combination of cytokine-enhanced vaccine and chemo-gene therapy as surgery adjuvant treatments for spontaneous canine melanoma
- Liliana M. E. Finocchiaro
- , Lucrecia Agnetti
- & Gerardo C. Glikin
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scFv6.C4 DNA vaccine with fragment C of Tetanus toxin increases protective immunity against CEA-expressing tumor
- Bianca Ferrarini Zanetti
- , Camila Pontes Ferreira
- & Sang Won Han
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