Blood–brain barrier articles from across Nature Portfolio

FLVCR2 is expressed in the blood–brain barrier of mouse and human, and is the major mediator of choline uptake into the brain.

A molecular mechanism for brain-specific angiogenesis operates under the control of Wnt7a/b ligands.

Vascular pathology may play important early role in Alzheimer’s disease (AD). Here, the authors show that β-amyloid induces transcriptomic signatures associated with accelerated apoptosis, impaired function and AD risk in human brain microvasculature.

The acid–base balance regulates cellular responses, but little has been known about its molecular mechanism. Here, the authors unveil a bicarbonate-sensing GPCR, GPR30, that underlies cerebral ischemia–reperfusion injury by regulating blood flow recovery.

The eye and the brain are both recognized as immune-privileged sites. Research now indicates that responses in the eye mirror those in the central nervous system (CNS), offering major implications for the treatment of CNS cancers and infections.

One of the long-term sequelae associated with SARS-CoV-2 infection is ‘brain fog’, which is shown in this study to be linked to systemic inflammation and leakiness of the blood–brain barrier.

Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive decline, compared to those with long COVID without any neurological symptoms.

We developed synthetic serum markers that can be expressed in the brain but are transported into the blood, enabling minimally invasive monitoring of gene expression in the brain with a simple blood test.

A juvenile hormone-degrading enzyme localized in the insect equivalent of the blood–brain barrier governs which social role, forager or soldier, worker carpenter ants fulfil.

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system that is driven by autoreactive lymphocytes. An in vivo CRISPR screen of T cell infiltration in a rat model of MS now identifies the genetic modules that control this key step in the immunopathology of MS.