Long COVID has remained an on-going public health issue in the years following the global pandemic. Here, we report blood–brain barrier disruption in patients with acute SARS-CoV-2 infection and brain fog, and patients presenting with long COVID, brain fog and cognitive decline, compared to those with long COVID without any neurological symptoms.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Sudre, C. H. et al. Attributes and predictors of long COVID. Nat. Med. 27, 626–631 (2021). A large study that examines the symptoms and presentation of long COVID.
Veksler, R. et al. Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players. Brain 143, 1826–1842 (2020). This paper reports BBB disruption in participants engaged in collision sports.
O’Keeffe, E. et al. Dynamic blood-brain barrier regulation in mild traumatic brain injury. J. Neurotrauma 37, 347–356 (2020). This clinical research paper showed BBB disruption directly linked to head trauma in rugby players and mixed martial arts fighters.
Abbott, N. J., Patabendige, A. A., Dolman, D. E., Yusof, S. R. & Begley, D. J. Structure and function of the blood-brain barrier. Neurobiol. Dis. 37, 13–25 (2010). A review that presents an overview of the structure and function of the BBB.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: Greene, C. et al. Blood–brain barrier disruption and sustained systemic inflammation in individuals with long COVID-associated cognitive impairment. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01576-9 (2024)
Rights and permissions
About this article
Cite this article
Leaky blood–brain barrier in long-COVID-associated brain fog. Nat Neurosci 27, 395–396 (2024). https://doi.org/10.1038/s41593-024-01577-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41593-024-01577-8