Featured
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Article |
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells
AAV therapy in dogs leads to clonal expansions of transduced cells.
- Giang N. Nguyen
- , John K. Everett
- & Denise E. Sabatino
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Article |
Inducible de novo expression of neoantigens in tumor cells and mice
A system to express neoantigens in tumor cells and mice circumvents central T cell tolerance.
- Martina Damo
- , Brittany Fitzgerald
- & Nikhil S. Joshi
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Article |
Precision mouse models with expanded tropism for human pathogens
Implantation of lung tissue into humanized mice enables in vivo study of the human immune response to pathogens.
- Angela Wahl
- , Chandrav De
- & J. Victor Garcia
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Article |
Tubuloids derived from human adult kidney and urine for personalized disease modeling
‘Tubuloids’ grown from human kidney tissue and urine aid the study of BK virus infection, Wilms tumors and cystic fibrosis.
- Frans Schutgens
- , Maarten B Rookmaaker
- & Hans Clevers
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Article |
A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells
Three linked microfluidic chips model transport across the blood–brain barrier.
- Ben M Maoz
- , Anna Herland
- & Kevin Kit Parker
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Letter |
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
A method called PRISM rapidly identifies drug candidates that are effective against specific cancer cell lines.
- Channing Yu
- , Aristotle M Mannan
- & Todd R Golub
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Letter |
GFP-specific CD8 T cells enable targeted cell depletion and visualization of T-cell interactions
T cells specific for GFP allow depletion of specific cell types in mice.
- Judith Agudo
- , Albert Ruzo
- & Brian D Brown
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Editorial |
Modeling credentials
The time has come to systematically assess the pros and cons of different mouse models as predictors of patient responses to cancer therapies.
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News & Views |
New models of human immunity
Two humanized mouse models open up a plethora of research applications.
- Hergen Spits
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Article |
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
Mice engineered to express the entire human variable immunoglobulin region enable rapid isolation of high-affinity antibodies specific for antigens of interest.
- E-Chiang Lee
- , Qi Liang
- & Allan Bradley
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Letter |
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
The use of shRNA in vivo to investigate genes involved in proliferation and survival is confounded by the competitive advantage of cells with insufficient shRNA expression. Zuber et al. address this issue with a system that combines Tet-regulated shRNA expression, two fluorescent reporters and robust transactivator production.
- Johannes Zuber
- , Katherine McJunkin
- & Scott W Lowe
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Analysis |
Large-scale in silico modeling of metabolic interactions between cell types in the human brain
The metabolism of tissues often involves interactions between several types of cell. Lewis et al. model metabolism within and between neurons in the human brain, gaining insight into energy metabolism and Alzheimer's disease.
- Nathan E Lewis
- , Gunnar Schramm
- & Bernhard Ø Palsson
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Article |
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
Genetically engineered mouse models of cancer simulate the spontaneous development of tumors in their native tissue environment. Singh et al. establish their ability to predict the efficacy of different treatment regimens by comparing clinical trial results to equivalent experiments in mutated KRAS-driven mouse models of pancreatic and lung cancer.
- Mallika Singh
- , Anthony Lima
- & Leisa Johnson
Breaking boundaries in whole-body imaging and disease understanding with wildDISCO
Mouse phenotyping sheds light on rare disease
CRISPR mouse model boom, rat model renaissance
What's in a stomach?