Bacterial transcription articles within Nature

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• Article
  07 February 2024 | Open Access

  Translation selectively destroys non-functional transcription complexes

  Translation actively dislodges stalled transcription elongation complexes (ECs) from damaged DNA, which enables lesion repair and restoration of transcription activity, and coupled ribosomes discriminate between active ECs and stalled ECs, ensuring destruction of only the latter.

  • Jason Woodgate
  • , Hamed Mosaei
  •  & Nikolay Zenkin

• Article | 03 February 2021

  Molecular basis for control of antibiotic production by a bacterial hormone

  X-ray crystallography and cryo-electron microscopy structures of the transcriptional repressor of the methylomycin gene cluster, MmfR, reveal the molecular basis for regulation of antibiotic biosynthesis by AHFCA hormones in Actinobacteria.

  • Shanshan Zhou
  • , Hussain Bhukya
  •  & Christophe Corre

• Article | 26 August 2020

  Functionally uncoupled transcription–translation in Bacillus subtilis

  In Bacillus subtilis, unlike in Escherichia coli, transcription and translation of genes are not tightly coupled, and pioneering ribosomes lag substantially behind RNA polymerases.

  • Grace E. Johnson
  • , Jean-Benoît Lalanne
  •  & Gene-Wei Li

• Article | 20 January 2016

  Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions

  Using dual RNA-seq technology to profile RNA expression simultaneously in the bacterial pathogen Salmonella and its host during infection reveals molecular phenotypes of small noncoding RNAs in the infection process.

  • Alexander J. Westermann
  • , Konrad U. Förstner
  •  & Jörg Vogel

• Letter | 23 February 2011

  Co-directional replication–transcription conflicts lead to replication restart

  As the rates of replication and transcription are different, the machineries that carry out these processes are bound to clash on DNA. In contrast to results from head-on collisions, co-directional encounters have been shown to have mild effects in vitro, requiring no additional replication restart factors. It is now shown that in bacterial cells, both types of events require the activities of restart proteins to resume replication when a transcription complex is encountered.

  • Houra Merrikh
  • , Cristina Machón
  •  & Panos Soultanas