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| Open AccessBacterial pathogens deliver water- and solute-permeable channels to plant cells
The bacterial effector proteins of the AvrE family function as membrane channels in plant cells, enabling the passage of water and solutes from host cells to support pathogen growth, and disrupting the viability of the host cell.
- Kinya Nomura
- , Felipe Andreazza
- & Sheng Yang He
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Article
| Open AccessA Pseudomonas aeruginosa small RNA regulates chronic and acute infection
A study examining bacterial gene expression in human-derived samples identifies a gene encoding a small RNA and describes how it orchestrates the transition between chronic and acute infection in Pseudomonas aeruginosa.
- Pengbo Cao
- , Derek Fleming
- & Marvin Whiteley
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Enterococci enhance Clostridioides difficile pathogenesis
Enterococci enhance the fitness and pathogenesis of Clostridioides difficile in the gut by altering the amino acid composition and providing signals that increase its virulence towards the host.
- Alexander B. Smith
- , Matthew L. Jenior
- & Joseph P. Zackular
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Article
| Open AccessArchaic chaperone–usher pili self-secrete into superelastic zigzag springs
The Csu pili of the multidrug-resistant nosocomial pathogen Acinetobacter baumannii assemble into an ultrathin zigzag architecture secured by a clinch mechanism that provides the pilus with high mechanical stability and superelasticity.
- Natalia Pakharukova
- , Henri Malmi
- & Anton V. Zavialov
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Article
| Open AccessStructure and dynamics of a mycobacterial type VII secretion system
A cryo-electron microscopy structure of the inner membrane complex of the ESX-5 type VII secretion system of Mycobacterium tuberculosis reveals an important role of interactions with MycP5 protease for complex integrity.
- Catalin M. Bunduc
- , Dirk Fahrenkamp
- & Thomas C. Marlovits
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Article |
Type III-A CRISPR immunity promotes mutagenesis of staphylococci
In Staphylococcus epidermidis and Staphylococcus aureus, non-specific DNase activity of the type III-A CRISPR–Cas system increases the rate of mutations in the host and accelerates the evolution of resistance to antibiotics and to phage.
- Charlie Y. Mo
- , Jacob Mathai
- & Luciano A. Marraffini
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Bacterial cGAS-like enzymes synthesize diverse nucleotide signals
A bacterial family of cGAS/DncV-like nucleotidyltransferases synthesizes a diverse range of cyclic dinucleotide and trinucleotide compounds that are likely to modulate the interaction of both pathogens and commensal microbiota with their animal and plant hosts.
- Aaron T. Whiteley
- , James B. Eaglesham
- & Philip J. Kranzusch
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Letter |
High-avidity IgA protects the intestine by enchaining growing bacteria
Oral-vaccine-induced IgA cross-links growing bacteria into clonal aggregates, inhibiting pathogenesis, adaption and the spread of antimicrobial resistance genes.
- Kathrin Moor
- , Médéric Diard
- & Emma Slack
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Letter |
Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body
The authors report the structure of the assembled membrane spanning ring forming proteins of the Salmonella Typhimurium injectisome basal body, including the first atomic structure of a member of the secretin family of outer-membrane pores.
- L. J. Worrall
- , C. Hong
- & N. C. J. Strynadka
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Letter |
Fucose sensing regulates bacterial intestinal colonization
FusKR, a fucose-sensing two-component system, has been identified in enterohaemorrhagic E. coli, linking fucose utilization and virulence factor gene expression and providing insight into how sensing of a host signal can facilitate bacterial colonization.
- Alline R. Pacheco
- , Meredith M. Curtis
- & Vanessa Sperandio
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Letter |
A Xanthomonas uridine 5′-monophosphate transferase inhibits plant immune kinases
The plant pathogen Xanthomonas campestris effector, AvrAC, is shown to have uridine 5′-monophosphate transferase activity, enabling it to interfere with plant immune signalling by using this protein modification.
- Feng Feng
- , Fan Yang
- & Jian-Min Zhou
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Article |
Structural basis for iron piracy by pathogenic Neisseria
Structural analysis reveals the iron scavenging mechanism used by Neisseria species, involving TbpA and TbpB proteins, and sheds light on how human transferrin is specifically targeted.
- Nicholas Noinaj
- , Nicole C. Easley
- & Susan K. Buchanan
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Research Highlights |
Bacterial weapon: inflammation
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Research Highlights |
How a bacterium grabs the gut
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Research Highlights |
A key for bacterial entry
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News |
German E. coli outbreak caused by previously unknown strain
Genome sequence gives clues to microbe's sticking power.
- Marian Turner
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Letter |
The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold
Pathogenic Escherichia coli translocate many proteins into the host cell to promote virulence. It is now shown that one of these proteins, EspG, which is present in enterohaemorrhagic E. coli, interferes with the host signalling network.
- Andrey S. Selyunin
- , Sarah E. Sutton
- & Neal M. Alto
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Research Highlights |
Microbiology: Salmonella gets help from host
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Letter |
Satellite phage TLCφ enables toxigenic conversion by CTX phage through dif site alteration
Bacterial chromosomes often carry integrated genetic elements (such as plasmids and prophages) that contribute to the evolutionary fitness of the host bacterium. In Vibrio cholerae, a prophage encodes cholera toxin. Here, the events that led to the acquisition of phage DNA have been reconstructed, revealing the cooperative interactions between multiple filamentous phages that contributed to the emergence of virulent V. cholerae strains.
- Faizule Hassan
- , M. Kamruzzaman
- & Shah M. Faruque
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Letter |
Modulation of Shigella virulence in response to available oxygen in vivo
The bacterium Shigella flexneri, which causes dysentery, infects the gastrointestinal tract. It uses a type III secretion system as a molecular syringe to inject virulence factors into host cells during infection. It is now suggested that varying oxygen availability during different phases of infection tightly regulates expression of the secretion system, as well as the secretion of virulence factors.
- Benoit Marteyn
- , Nicholas P. West
- & Christoph M. Tang
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