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| Open AccessDiversification of bacterial genome content through distinct mechanisms over different timescales
Populations of the pathogenic bacterium Streptococcus pneumoniaeconsist of distinct co-circulating lineages. Here, the authors show lineages are characterized by particular combinations of stable genomic islands, whereas prophage and restriction-modification systems vary over short timescales.
- Nicholas J. Croucher
- , Paul G. Coupland
- & William P. Hanage
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Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster
Pneumococci can cause a variety of bacterial infections including conjunctivitis. Here, Valentino et al.show that most conjunctivitis-causing pneumococci belong to a closely related group of strains that possess a unique set of putative virulence factors.
- Michael D. Valentino
- , Abigail Manson McGuire
- & Michael S. Gilmore
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Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences
Phosphorothioate (PT) DNA modifications are widespread in bacteria and play a critical role in cell physiology. Here, the authors develop two sequence-based technologies to map PT modifications across bacterial genomes.
- Bo Cao
- , Chao Chen
- & Peter C. Dedon
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Article
| Open AccessPhysiological and genomic features of highly alkaliphilic hydrogen-utilizing Betaproteobacteria from a continental serpentinizing site
Microbes can dwell in highly alkaline environments in the absence of obvious food sources. Here, the authors describe physiological and genomic features of a group of bacteria that live on hydrogen, calcium carbonate and oxygen at a very high pH.
- Shino Suzuki
- , J. Gijs Kuenen
- & Kenneth H. Nealson
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Genomics of DNA cytosine methylation in Escherichia coli reveals its role in stationary phase transcription
How DNA cytosine methylation affects gene expression inEscherichia coli is poorly understood. Here, the first genome-wide study of cytosine methylation in E. coliat single-base resolution reveals that cytosine methylation controls the expression of genes during the stationary growth phase.
- Christina Kahramanoglou
- , Ana I. Prieto
- & Aswin S.N. Seshasayee