Asymmetric catalysis articles from across Nature Portfolio

Asymmetric catalysis is a type of catalysis in which a chiral catalyst directs the formation of a chiral compound such that formation of one particular stereoisomer is favoured. Since the catalyst is not consumed in this process it may be used in a substoichiometric quantity – potentially improving efficiency and avoiding waste.


Latest Research and Reviews

News and Comment

  • News & Views |

    Stereocontrolled radical polymerizations are elusive, owing to the difficulty of controlling facial addition at a propagating planar, sp2 radical chain end. Now, cobalt–porphyrin initiators are reported that enable the preparation of well-defined, highly isotactic polyacrylamides at low Lewis acid loading.

    • Kasun Wekasinghe
    •  & Aaron J. Teator
  • News & Views |

    Direct, stereocontrolled functionalization of ubiquitous C(sp3)–H bonds represents the most efficient route towards highly valuable molecules from feedstock chemicals. Now, diverse, enantioenriched, unnatural α-amino acids are obtained from readily available carboxylic acids in one step via iron-catalysed asymmetric nitrene transfer, overcoming the reactivity and selectivity challenges of intermolecular C–H amination.

    • Tuan Anh Trinh
    •  & Jennifer M. Schomaker
  • News & Views |

    The selective removal of one oxygen atom from sulfones, without over-reduction to sulfide, is a challenging task. Now, through organocatalysis and incorporation of a cyano group into the sulfone, an asymmetric deoxygenation strategy has been developed, providing an efficient method for the synthesis of chiral sulfinyl compounds.

    • Elżbieta Wojaczyńska
    •  & Jacek Wojaczyński
    Nature Chemistry 15, 165-166
  • News & Views |

    Synthesis of chiral aryl–alkene bond axes is a challenge owing to axial instability and specific substrate requirements. Now, arylboration of alkynes by sequentially using two catalysts yields axially chiral alkenylboronates with excellent stereocontrol.

    • Jun Kee Cheng
    •  & Bin Tan
    Nature Synthesis 2, 83-85
  • News & Views |

    Controlling the stereochemical outcomes of chemical reactions is essential in modern chemical synthesis and manufacturing. Now, a nickel-catalysed, stereoselective hydrometalation and enantioconvergent alkyl–alkyl coupling of alkenyl boronic esters and α-bromo carbonyl derivatives has been achieved to provide single stereoisomers.

    • Mark D. Greenhalgh
    •  & Stephen P. Thomas
    Nature Catalysis 5, 1079-1080
  • News & Views |

    Controllable cleavage and conversion of strong C(sp3)–H bonds remains a challenging task in organic synthesis. Here, a reaction design combining hydrogen atom transfer and copper catalysis is developed which allows enantioselective alkene difunctionalization using aliphatic C–H bond activation.

    • Lei Gong
    Nature Synthesis 1, 915-916