The direct carbonylation of alkanes with CO suffers from low conversion owing to equilibrium constraints. Now, a strategy is presented that combines reversible alkane carbonylation with an asymmetric transformation to overcome the equilibrium limitations, enabling the synthesis of chiral β- and α-amino ketones from alkanes, CO and anilines.
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References
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This is a summary of: Ding, W.-W. et al. Enantioselective synthesis of β- and α-amino ketones through reversible alkane carbonylation. Nat. Synth. https://doi.org/10.1038/s44160-023-00476-3 (2024).
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Enantioselective assembly of β- and α-amino ketones from alkanes, CO and anilines. Nat. Synth 3, 432–433 (2024). https://doi.org/10.1038/s44160-023-00481-6
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DOI: https://doi.org/10.1038/s44160-023-00481-6
