Patents |
Featured
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Article |
Nature-inspired design of motif-specific antibody scaffolds
Engineering motif-specific 'hot spots' into an antibody scaffold yields antibodies with high affinity to targets containing phosphoserine, phosphothreonine or phosphotyrosine.
- James T Koerber
- , Nathan D Thomsen
- & James A Wells
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Letter |
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
In a bacterial expression system, two half antibodies, each having distinct light chains, spontaneously assemble into an intact bispecific molecule with natural antibody architecture
- Christoph Spiess
- , Mark Merchant
- & Justin M Scheer
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Perspective |
Beyond natural antibodies: the power of in vitro display technologies
- Andrew R M Bradbury
- , Sachdev Sidhu
- & John McCafferty
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Editorial |
Similarity trials
A European guideline on biosimilar monoclonal antibodies suggests smaller trials with homogeneous, younger patient groups may suffice for marketing authorization.
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Letter |
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization
The typical therapeutic antibody binds only two target antigen molecules during its lifetime. Igawa et al. describe a method for engineering antibody recycling in vivo, suggesting an approach to reduce the size and/or frequency of dosage with therapeutic antibodies.
- Tomoyuki Igawa
- , Shinya Ishii
- & Kunihiro Hattori
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Letter |
Monoclonal antibodies isolated without screening by analyzing the variable-gene repertoire of plasma cells
Isolation of antigen-specific antibodies or antibody fragments, whether through B-cell immortalization or recombinant libraries, generally requires laborious screening. Reddy et al. circumvent this step using high-throughput sequencing of plasma cells and bioinformatic analysis of the variable-gene repertoire.
- Sai T Reddy
- , Xin Ge
- & George Georgiou
