Featured
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Review Article |
Cheating evolution: engineering gene drives to manipulate the fate of wild populations
RNA-guided endonucleases have the potential to revolutionize the engineering of synthetic gene drives, which may be particularly useful for the control of vector-borne diseases. Here, the authors review different types of engineered gene drives and their potential applications, as well as considerations regarding the safety and regulation of gene drives for the manipulation of wild populations.
- Jackson Champer
- , Anna Buchman
- & Omar S. Akbari
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Progress |
Genomically humanized mice: technologies and promises
This article describes the promising technologies for generating humanized mouse models — that is, mouse strains containing large sections of human coding and non-coding sequences — for the purposes of improving our understanding of basic genome function and disease and discovering effective therapies.
- Anny Devoy
- , Rosie K. A. Bunton-Stasyshyn
- & Elizabeth M. C. Fisher
Rewriting the rules of inheritance