Correspondence |
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Letter |
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
Many proteases are important drug targets, but identification of their substrates remains challenging. By using polymers to selectively isolate N-terminal peptides generated by proteolysis of complex samples, Kleifeld et al. identify substrates of clinically relevant proteases with broad specificity.
- Oded Kleifeld
- , Alain Doucet
- & Christopher M Overall
Minimum information about a protein affinity reagent (MIAPAR)