Adaptive immunity articles within Nature Reviews Cardiology

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  • Journal Club |

    Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis.

    • Mohsen Shoaran
    •  & Pasquale Maffia

  • Review Article |

    In this Review, Varga and colleagues provide an overview of the evidence on immune checkpoint inhibitor-induced heart failure and cardiac dysfunction that is unrelated to myocarditis, and discuss how pharmacological targeting of immune checkpoints might be a potential strategy to treat heart failure.

    • Tamás G. Gergely
    • , Zsófia D. Drobni
    •  & Zoltán V. Varga

  • Review Article |

    In this Review, Guzik and colleagues discuss immune and inflammatory mechanisms of hypertension, including upstream regulators and downstream effectors as well as the complex interplay between the immune system, blood pressure regulation and end-organ damage, which can help to identify new targets for therapeutic interventions.

    • Tomasz J. Guzik
    • , Ryszard Nosalski
    •  & Grant R. Drummond

  • Review Article |

    In this Review, the authors discuss the clinical and experimental data on immunomodulatory effects of evidence-based treatments for heart failure and their primary mechanisms of action, and highlight potential therapeutic targets and opportunities for the development and application of novel immunomodulatory treatments for heart failure.

    • George Markousis-Mavrogenis
    • , Lukas Baumhove
    •  & Peter van der Meer

  • Comment |

    IgM antibodies have gained much attention as risk markers of atherosclerotic cardiovascular disease, but the exact antigenic determinants and the full spectrum of functions remain to be defined. A better understanding of the potentially diverse nature of the antigens that they recognize will help to dissect the function of IgM in atherosclerosis.

    • Justine Deroissart
    •  & Christoph J. Binder

  • Clinical Outlook |

    Immune checkpoint inhibitors (ICIs) have become a pillar of cancer therapy. The cardiovascular complications of ICIs extend beyond myocarditis and can involve any component of the cardiovascular system, including the pericardium, coronary arteries and conduction system. Clinicians caring for patients treated with ICIs must be vigilant for the cardiovascular complications of these therapies, which might portend a poor prognosis.

    • Kiranbir Josan
    •  & Tomas G. Neilan

  • Review Article |

    In this Review, the authors summarize the latest advances in cardioimmunology and discuss experimental tools and strategies that are currently available for the study of immune cells, guiding readers through case-based examples to provide recommendations for the use of immunological tools and strategies in the study of immune cells in cardiac disease.

    • Anthony Wong
    • , Homaira Hamidzada
    •  & Slava Epelman

  • Review Article |

    In this Review, the authors provide an overview of the immune cells involved in atherosclerosis, discuss preclinical research and published and ongoing clinical trials assessing the therapeutic potential of targeting the immune system in atherosclerosis, highlight emerging therapeutic targets from preclinical studies and identify challenges for successful clinical translation.

    • Suzanne E. Engelen
    • , Alice J. B. Robinson
    •  & Claudia Monaco

  • Review Article |

    Accumulating evidence supports the critical role of T cells as drivers and modifiers of atherosclerosis. In this Review, Ley and colleagues describe the latest advances in our understanding of the role of T cell subsets in atherosclerosis, discuss the process of T cell homing to atherosclerotic plaques and highlight potential T cell-related therapies for atherosclerosis.

    • Ryosuke Saigusa
    • , Holger Winkels
    •  & Klaus Ley

  • Review Article |

    Inflammation has an important role in the pathogenesis of acute and chronic heart failure. This Review summarizes the latest findings on the role of the innate and adaptive immune systems in the pathogenesis of heart failure, and highlights the results of phase III clinical trials of therapies targeting inflammatory processes in this condition, such as anti-inflammatory and immunomodulatory strategies.

    • Luigi Adamo
    • , Cibele Rocha-Resende
    •  & Douglas L. Mann

  • Review Article |

    Chronic inflammation of the vascular wall is a hallmark of atherosclerosis. The authors of this Review discuss the role of various T and B cell subsets in the development of atherosclerotic lesions and summarize potential treatment strategies that are based on the modulation of the adaptive immune response.

    • Charlotte Lahoute
    • , Olivier Herbin
    •  & Alain Tedgui

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