Volume 22 Issue 8, August 2015

Volume 22 Issue 8

The flexibility of filamentous plant viruses has been a challenge to their structural characterization.A cryo-EM structure of the bamboo mosaic potexvirus now elucidates the molecular basis of this flexibility. Cover image by © moodboard/Thinkstock (pp 642–644)

News and Views

Articles

  • Article |

    Plasmepsin V is an aspartyl protease essential for export of effector proteins to Plasmodium-infected erythrocytes. A new inhibitor blocks plasmepsin V and inhibits parasite growth; it has also allowed solving the structure of P. vivax plasmepsin V.

    • Anthony N Hodder
    • , Brad E Sleebs
    • , Peter E Czabotar
    • , Michelle Gazdik
    • , Yibin Xu
    • , Matthew T O'Neill
    • , Sash Lopaticki
    • , Thomas Nebl
    • , Tony Triglia
    • , Brian J Smith
    • , Kym Lowes
    • , Justin A Boddey
    •  & Alan F Cowman
  • Article |

    Extensive glycan microarray and structural analyses reveal that human intelectin-1 interacts selectively with microbial glycan epitopes through recognition of a terminal 1,2-diol group, an interaction that would be blocked in human glycans such as α-Neu5Ac.

    • Darryl A Wesener
    • , Kittikhun Wangkanont
    • , Ryan McBride
    • , Xuezheng Song
    • , Matthew B Kraft
    • , Heather L Hodges
    • , Lucas C Zarling
    • , Rebecca A Splain
    • , David F Smith
    • , Richard D Cummings
    • , James C Paulson
    • , Katrina T Forest
    •  & Laura L Kiessling
  • Article |

    Chemical genetics, proteomics and biochemistry are used to probe the functions of SR protein kinases. An identified target of Dsk1 is spliceosomal protein Bpb1 (SF1), whose phosphorylation increased its binding to introns with nonconsensus splice sites.

    • Jesse J Lipp
    • , Michael C Marvin
    • , Kevan M Shokat
    •  & Christine Guthrie
  • Article |

    Chromatin reassembly after replication requires recycling of old and deposition of new histones. Structural insights into how MCM2, part of the replicative helicase, interacts with H3–H4 suggest a function in histone recycling at replication forks.

    • Hongda Huang
    • , Caroline B Strømme
    • , Giulia Saredi
    • , Martina Hödl
    • , Anne Strandsby
    • , Cristina González-Aguilera
    • , Shoudeng Chen
    • , Anja Groth
    •  & Dinshaw J Patel
  • Article |

    Structural studies of human polysialyltransferase ST8SialII in apo form and in complex with donor sugar and sulfated glycan acceptor shed light on the substrate binding and specificity as well as the catalytic activity of this class of polysialyltransferases.

    • Gesa Volkers
    • , Liam J Worrall
    • , David H Kwan
    • , Ching-Ching Yu
    • , Lars Baumann
    • , Emilie Lameignere
    • , Gregory A Wasney
    • , Nichollas E Scott
    • , Warren Wakarchuk
    • , Leonard J Foster
    • , Stephen G Withers
    •  & Natalie C J Strynadka

Brief Communication

  • Brief Communication |

    Flexible filamentous plant viruses, which cause substantial crop damage worldwide, have eluded structural characterization so far. The cryo-EM structure of BaMV now reveals the virus architecture and the structural basis of its flexibility.

    • Frank DiMaio
    • , Chun-Chieh Chen
    • , Xiong Yu
    • , Brandon Frenz
    • , Yau-Heiu Hsu
    • , Na-Sheng Lin
    •  & Edward H Egelman

Corrigendum