Volume 22 Issue 6, June 2015

Volume 22 Issue 6

Competition of CRY1 with coactivators for binding to the BMAL1 transcriptional activation domain regulates circadian cycling.Cover image by © Ryan McVay /Photodisc / Thinkstock (pp 476–484, News and Views p 435)

Correspondence

  • Correspondence | | open

    • Aleksandras Gutmanas
    • , Paul D Adams
    • , Benjamin Bardiaux
    • , Helen M Berman
    • , David A Case
    • , Rasmus H Fogh
    • , Peter Güntert
    • , Pieter M S Hendrickx
    • , Torsten Herrmann
    • , Gerard J Kleywegt
    • , Naohiro Kobayashi
    • , Oliver F Lange
    • , John L Markley
    • , Gaetano T Montelione
    • , Michael Nilges
    • , Timothy J Ragan
    • , Charles D Schwieters
    • , Roberto Tejero
    • , Eldon L Ulrich
    • , Sameer Velankar
    • , Wim F Vranken
    • , Jonathan R Wedell
    • , John Westbrook
    • , David S Wishart
    •  & Geerten W Vuister

News and Views

  • News & Views |

    How do molecular interactions determine the period length of a circadian oscillator? In mammals, a disordered region of the BMAL1 transcription factor that is able to interact with activators or repressors seems to perform this function.

    • Ka Yi Hui
    •  & Jürgen A Ripperger
  • News & Views |

    Sex-determining transcription factors recognize their genomic target sites through mechanisms of DNA base-and-shape readout in combination with cooperative binding. Murphy et al. reveal that for one such transcription factor, DMRT1, the DNA sequence-and-shape features of its binding sites determine whether it binds DNA as a dimer, trimer or tetramer; they also characterize protein-DNA contacts that affect gender phenotypes in flies and humans.

    • Remo Rohs
    • , Ana Carolina Dantas Machado
    •  & Lin Yang
  • News & Views |

    Ten years ago, the repulsive guidance molecules (RGMs), a family of three glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures provide exciting insights into how RGM co-receptors may modulate BMP signaling.

    • Thomas D Mueller

Research Highlights

Articles

Brief Communication