Ten years ago, the repulsive guidance molecules (RGMs), a family of three glycosylphosphatidylinositol–anchored glycoproteins, were identified as highly specific co-receptors of the bone morphogenetic proteins (BMPs). Newly reported crystal structures provide exciting insights into how RGM co-receptors may modulate BMP signaling.
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Mueller, T. RGM co-receptors add complexity to BMP signaling. Nat Struct Mol Biol 22, 439–440 (2015). https://doi.org/10.1038/nsmb.3037
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DOI: https://doi.org/10.1038/nsmb.3037
