Volume 22 Issue 4, April 2015

Volume 22 Issue 4

Jopling, Proudfoot and colleagues show that long noncoding RNA transcripts hosting microRNAs use Microprocessor to terminate transcription, thus revealing a novel RNase III-mediated transcriptional termination pathway. Cover image by © Thinkstock Images. pp 319–327, News and Views p 279

News and Views

  • News & Views |

    Although the two B-family human DNA polymerases, pol δ and pol ε, are responsible for the bulk of nuclear genome replication, at least 14 additional polymerases have roles in nuclear DNA repair and replication. In this issue, newly reported crystal structures of two specialized A-family polymerases, pol ν and pol θ, expose these enzymes' strategies for handling aberrant DNA ends.

    • William A Beard
    •  & Samuel H Wilson
  • News & Views |

    Circadian regulation of epigenetic chromatin marks drives daily transcriptional oscillation of thousands of genes and is intimately linked to cellular metabolism and bioenergetics. New work links circadian fluctuations in the activity of the SIRT1 deacetylase, a sensor of the cellular energy state, to histone-methylation changes and the circadian expression of clock-controlled genes.

    • Luisa Tasselli
    •  & Katrin F Chua
  • News & Views |

    Pioneering studies in voltage-gated potassium channels have described movement of the voltage-sensing domain (VSD) S4 helix across the membrane electric field in molecular detail, but much less is known regarding opening of the intrinsic proton pore within VSDs of voltage-dependent proton channels. By systematically probing local kinematics, a new study reveals that movements in helix S1 correlate with pore opening and are distinct from voltage-sensing movements of the charged S4 segment.

    • Marcel P Goldschen-Ohm
    •  & Baron Chanda
  • News & Views |

    Transcriptional termination is an important yet incompletely understood aspect of gene expression. Proudfoot, Jopling and colleagues now identify a new Microprocessor-mediated mechanism of transcriptional termination, which acts specifically on long noncoding transcripts that serve as microRNA precursors.

    • Sven Diederichs

Research Highlights

Articles

Brief Communications