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New research demonstrates that antibodies from patients with fibromyalgia induce sensory hypersensitivities in recipient mice, suggesting an autoimmune basis for the disease as well as new therapeutic possibilities.
New research shows that combination therapy for septic arthritis in mice considerably reduces intracellular bacteria in synovial tissue and protects against joint damage.
A new study describes an anti-inflammatory signalling pathway mediated by TNFR2 and the signalling molecule 14-3-3ε and the effects of this pathway on macrophage polarization.
New research shows that platelets inhibit regulatory T cell immunosuppressive activity in systemic lupus erythematosus via P-selectin–PSGL1 interaction.
An anti-CD38 monoclonal antibody and an in vivo gene-editing approach show promise for the treatment of different forms of systemic amyloidosis in separate clinical trials.
Short telomere length is implicated in lung diseases and can be caused by mutations in telomere genes. Acquired autoimmunity directed against components of the telomere system is now reported in some patients with systemic sclerosis or idiopathic pulmonary fibrosis, suggesting a novel explanation for short telomeres in these diseases.
The 2021 ACR guideline for the treatment of rheumatoid arthritis provides an update on several important topics, including the use of targeted synthetic DMARDs (tsDMARDs). But how does the new guideline compare to EULAR recommendations, and is the growing importance of tsDMARDs adequately accounted for?
In this Review, the authors summarize and discuss the existing evidence on the incidence, prevalence and mortality of systemic lupus erythematosus across different world regions, with a focus on studies from the past 5 years.
Hypertension and osteoarthritis are associated with each other epidemiologically and share several molecular pathways. In this Review, the authors examine the crossover between these two conditions and propose the repurposing of antihypertensive medications to treat osteoarthritis.
Interactions between stromal cells and lymphocytes contribute to the pathogenesis of various autoimmune and inflammatory diseases. In this Review, the authors discuss the importance and heterogeneity of these interactions in three diseases: rheumatoid arthritis, psoriatic arthritis and systemic lupus erythematosus.
Physical function is an important contributor towards a patient’s quality of life, but is often neglected in management strategies for axial spondyloarthritis (axSpA). This Review provides guidance on determinants and assessments of physical function in axSpA.
