Confirmation that the IL-1 inhibitor rilonacept reduces gout flare occurrence during the initiation of urate-lowering therapy (ULT) has come from a phase III trial in a multi-ethnic cohort. Adults with hyperuricaemia, gout and ≥2 flares within the past year (n = 248; 53.2% white, 33.1% Asian, 13.7% black) began ULT with allopurinol alongside a weekly subcutaneous dose of placebo, 80 mg rilonacept or 160 mg rilonacept for 16 weeks. During this time, 43.9% of patients in the placebo group had no flares compared with 71.3% and 72.6% in the rilonacept groups (P ≤0.0001); also, significantly fewer patients had multiple flares with rilonacept than placebo.
ORIGINAL RESEARCH PAPER
Mitha, E. et al. Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial. Rheumatology (Oxford) doi:10.1093/rheumatology/ket114
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Efficacy of rilonacept in preventing gout flare during ULT. Nat Rev Rheumatol 9, 259 (2013). https://doi.org/10.1038/nrrheum.2013.51
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DOI: https://doi.org/10.1038/nrrheum.2013.51