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Practice in relation to administration of methotrexate varies considerably despite its prominent place in the treatment arsenal for various rheumatic diseases. A multinational initiative has developed recommendations, based on the literature and in consultation with a large panel of rheumatologists, for use of this drug.
Tumor necrosis factor inhibitors are fast acting, highly effective and well tolerated by the majority of patients, but their safety in pregnant women remains a matter of debate. The latest research weighs in on the issue.
The ability to conduct genetic association studies on a genome-wide scale has revolutionized approaches to reveal the genetic basis of autoimmune diseases. A comparison by Zhernakova and colleagues of the known susceptibility genes in 11 immune-related diseases reveals evidence for shared gene effects and common pathogenetic mechanisms.
