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Volume 19 Issue 4, April 2023

Extracellular protein homeostasis, inspired by the Review on p235.

Cover design: Philip Patenall


  • Prediction tools offer great promise for clinicians in the prevention and treatment of psychosis, but none has been routinely implemented. Greater methodological rigour in the development and evaluation of these tools, along with consideration of a range of performance criteria, is necessary to maximize their potential for improving clinical decision making.

    • Aida Seyedsalehi
    • Belinda Lennox


  • A growing understanding of the neurobiology of psychosis offers hope for an improvement in the standard of care; this includes the development of individualized, precision therapeutics. However, the path to precision psychiatry is long, and progress would be accelerated by greater collaboration with the fields of neurology and neuroscience.

    • Matcheri S. Keshavan
    • Brett A. Clementz
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Research Highlights

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  • Chronic neuropathic pain is a leading cause of disability that remains therapeutically challenging. Here, Fiore et al. review the immune mechanisms that contribute to the resolution of chronic neuropathic pain. Contributions of the gut microbiome and specialized pro-resolving mediators are also discussed, along with potential therapeutic strategies.

    • Nathan T. Fiore
    • Sophie R. Debs
    • Gila Moalem-Taylor
    Review Article
  • In this Review, the authors discuss recent efforts to predict disease onset, treatment response and disease outcome in individuals with psychosis. They cover genetic, biological, clinical and environmental predictive factors and assess whether the variation in outcomes is attributable to differences in the pathophysiology of psychosis.

    • Fiona Coutts
    • Nikolaos Koutsouleris
    • Philip McGuire
    Review Article
  • Wilson et al. review our current knowledge of the extracellular proteostasis system that protects the brain from the pathological consequences of extracellular protein aggregation. They discuss growing evidence that impairment of this system contributes to neuronal death in neurodegenerative diseases.

    • Mark R. Wilson
    • Sandeep Satapathy
    • Michele Vendruscolo
    Review Article
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  • In this Perspective, Edwards and colleagues present their opinion that functional neurological disorder is categorically different from feigning and malingering. They discuss clinical, epidemiological and experimental evidence in support of this view.

    • Mark J. Edwards
    • Mahinda Yogarajah
    • Jon Stone
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