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Prediction tools offer great promise for clinicians in the prevention and treatment of psychosis, but none has been routinely implemented. Greater methodological rigour in the development and evaluation of these tools, along with consideration of a range of performance criteria, is necessary to maximize their potential for improving clinical decision making.
A growing understanding of the neurobiology of psychosis offers hope for an improvement in the standard of care; this includes the development of individualized, precision therapeutics. However, the path to precision psychiatry is long, and progress would be accelerated by greater collaboration with the fields of neurology and neuroscience.
New research reports changes in serum blood–brain barrier (BBB) markers after bilateral tonic–clonic seizures, corroborating earlier observations in animal models.
A new study reports upregulation of pro-inflammatory cytokines and neurotrophic factors in the cerebrospinal fluid of individuals with a severe form of spinal muscular atrophy.
Chronic neuropathic pain is a leading cause of disability that remains therapeutically challenging. Here, Fiore et al. review the immune mechanisms that contribute to the resolution of chronic neuropathic pain. Contributions of the gut microbiome and specialized pro-resolving mediators are also discussed, along with potential therapeutic strategies.
In this Review, the authors discuss recent efforts to predict disease onset, treatment response and disease outcome in individuals with psychosis. They cover genetic, biological, clinical and environmental predictive factors and assess whether the variation in outcomes is attributable to differences in the pathophysiology of psychosis.
Wilson et al. review our current knowledge of the extracellular proteostasis system that protects the brain from the pathological consequences of extracellular protein aggregation. They discuss growing evidence that impairment of this system contributes to neuronal death in neurodegenerative diseases.
In this Perspective, Edwards and colleagues present their opinion that functional neurological disorder is categorically different from feigning and malingering. They discuss clinical, epidemiological and experimental evidence in support of this view.
