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Precision medicine for psychosis: a revolution at the interface of psychiatry and neurology

Nature Reviews Neurology volume 19, pages 193–194 (2023)Cite this article

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A growing understanding of the neurobiology of psychosis offers hope for an improvement in the standard of care; this includes the development of individualized, precision therapeutics. However, the path to precision psychiatry is long, and progress would be accelerated by greater collaboration with the fields of neurology and neuroscience.

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Fig. 1: Psychiatry hopes to move on from one-size-fits-all diagnostics and treatment.

References

  1. Hyman, S. E. Revolution stalled. Sci. Transl. Med. 4, 155cm11 (2012).

    Article  PubMed  Google Scholar 

  2. US FDA. Precision medicine. US Food and Drug Administration https://www.fda.gov/medical-devices/in-vitro-diagnostics/precision-medicine (2018).

  3. Espay, A. J. et al. Current concepts in diagnosis and treatment of functional neurological disorders. JAMA Neurol. 75, 1132–1141 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Clementz, B. A. et al. Psychosis biotypes: replication and validation from the B-SNIP Consortium. Schizophr. Bull. 48, 56–68 (2022).

    Article  PubMed  Google Scholar 

  5. Rosenthal, L. S. et al. The NINDS Parkinson’s disease biomarkers program. Mov. Disord. 31, 915–923 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Beauchaine, T. P., Constantino, J. N. & Hayden, E. P. Psychiatry and developmental psychopathology: unifying themes and future directions. Compr. Psychiatry 87, 143–152 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Gong, C. X., Dai, C. L., Liu, F. & Iqbal, K. Multi-targets: an unconventional drug development strategy for Alzheimer’s disease. Front. Aging Neurosci. 14, 837649 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. El-Alti, L., Sandman, L. & Munthe, C. Person centered care and personalized medicine: irreconcilable opposites or potential companions? Health Care Anal. 27, 45–59 (2019).

    Article  PubMed  Google Scholar 

  9. Keshavan, M. S., Price, B. H. & Martin, J. B. The convergence of neurology and psychiatry: the importance of cross-disciplinary education. J. Am. Med. Assoc. 324, 554–555 (2020).

    Article  Google Scholar 

  10. Samanta, D. GRIN2A-related epilepsy and speech disorders: a comprehensive overview with a focus on the role of precision therapeutics. Epilepsy Res. 189, 107065 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors thank J. McDowell and V. Shashi for their valuable input.

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Authors and Affiliations

  1. Beth Israel Deaconess Medical Center, Boston, MA, USA

    Matcheri S. Keshavan

  2. Harvard Medical School, Harvard University, Boston, MA, USA

    Matcheri S. Keshavan

  3. Department of Psychology, University of Georgia, Athens, GA, USA

    Brett A. Clementz

  4. Department of Neuroscience, University of Georgia, Athens, GA, USA

    Brett A. Clementz

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  1. Matcheri S. Keshavan
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  2. Brett A. Clementz
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Correspondence to Matcheri S. Keshavan.

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Keshavan, M.S., Clementz, B.A. Precision medicine for psychosis: a revolution at the interface of psychiatry and neurology. Nat Rev Neurol 19, 193–194 (2023). https://doi.org/10.1038/s41582-023-00788-0

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