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In this Case Study, the authors describe how sulfonylurea therapy not only restored glucose homeostasis, but also alleviated some of the neurological symptoms in a patient with intermediate DEND syndrome. Single-photon emission CT provided evidence of increased CNS blood flow and function that correlated with mental and motor improvements.
The extent to which white matter lesions affect brain function in elderly individuals has important implications for the development of drugs to treat cognitive impairment and dementia. In this article, Frisoni et al. argue that white matter lesions can contribute to cognitive impairment in elderly individuals, although their effects are minor when compared with those of other causes of cognitive deterioration, such as Alzheimer's disease.
Migraine is a common disabling brain disorder that—considering its clinical and economic impact—is understudied and in need of additional management options. In this Review, Peter Goadsby outlines new pharmaceutical and device-based approaches to migraine treatment by describing their potential mechanisms of action and the clinical data that are currently available.
Surgery is becoming a viable treatment option for an increasing proportion of patients with low-grade gliomas, but there is a lack of class I evidence to support its efficacy. In this Review, Pouratianet al. critically analyze the utility of surgery in low-grade glioma. They highlight recent technological advances that have made this approach safer and more accessible, and consider the challenges involved in designing trials to assess the extent to which aggressive resection improves prognosis.