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Quality geriatric kidney care extends beyond traditional therapy to care that balances the impact of both disease and treatment around how individuals manage their daily routines. In this Comment, we discuss clinical and policy changes that could benefit older people with advanced kidney disease.
A new study reports that common mitochondrial DNA variants in specific haplogroups induce metabolic alterations that affect the onset of common age-related diseases. Unravelling the role of this subtle, long-lasting burden of mitochondrial DNA variants on kidney homeostasis could provide novel insights into the pathophysiology of chronic kidney disease.
Four new reports uncover the lineage relationships between cells throughout the body using mutations in the genome as cellular barcodes. The mutational composition of different tissues provides insights into both developmental processes and organ homeostasis, and may have important implications for our understanding of hereditary diseases such as polycystic kidney disease.
Studies of lineage relationships in the mouse have advanced the understanding of kidney development and repair. Here, the authors discuss these advances as well as how the application of lineage tools to kidney organoids will facilitate studies of human lineage relationships.
The actions of immune cells within the kidney are of fundamental importance to kidney homeostasis and disease. This Review describes how live imaging of the kidney microvasculature in animal models has advanced our understanding of leukocyte behaviour in healthy and diseased kidneys.
Dyslipidaemia is a hallmark of chronic kidney disease (CKD), with insights from lipidomics studies suggesting that alterations in free fatty acid partitioning may contribute to CKD progression. This Review provides an introduction to lipidomics and discusses insights from lipidomics studies of relevance to CKD.
Novel non-steroidal mineralocorticoid receptor antagonists have a better safety profile than steroidal formulations. This Review examines the pro-inflammatory and profibrotic activity of mineralocorticoid receptor activation and discusses the therapeutic potential of MRAs in the treatment of diabetic kidney disease to improve kidney and cardiovascular outcomes.
