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Volume 21 Issue 11, November 2020

‘Expanding consciousness’ inspired by the Review on p611.

Cover design: Jennie Vallis.

Comment

  • Scientific meetings are an opportunity to promote research and researchers. Anne-Marie M. Oswald and Srdjan Ostojic describe ways to promote diversity at the conference podium.

    • Anne-Marie M. Oswald
    • Srdjan Ostojic

    Collection:

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Research Highlights

  • In mice, neuronally expressed opsin 5 acts as a deep brain violet light detector that allows hypothalamic neuron-mediated inhibition of thermogenesis.

    • Darran Yates
    Research Highlight
  • Progenitor cells in fetuses carrying Huntington disease-associated mutations show differences to controls, suggesting the disease may have a developmental component.

    • Natasha Bray
    Research Highlight
  • Glutamatergic neurons in the peri-locus coeruleus respond during ingestion of palatable food or drink and promote hedonic ingestion.

    • Natasha Bray
    Research Highlight
  • Strengthening of the developing retinogeniculate circuit in mouse pups is promoted by a neuronal receptor and locally restricted by the microglial release of the receptor’s ligand.

    • Natasha Bray
    Research Highlight
  • Juvenile social isolation in mice reduces a recruitment of medial prefrontal cortex (mPFC) to posterior paraventricular thalamus social behaviour circuit and thereby reduces sociability in adulthood.

    • Sian Lewis
    Research Highlight
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Reviews

  • Goal-directed primate behaviour is guided by abstract rules that group events and experiences into meaningful concepts. Here, Mansouri and colleagues discuss the distributed cortical and subcortical brain regions thought to underlie the formation, maintenance and implementation of abstract rules and propose a unified framework describing the neural architecture of rule-guided primate behaviour.

    • Farshad Alizadeh Mansouri
    • David J. Freedman
    • Mark J. Buckley
    Review Article
  • Recent advances in animal addiction models have emphasized translational challenges. In this Review, Venniro and colleagues introduce a reverse translational approach that may provide an ecologically relevant platform from which to discover new circuits, test new medications and improve translation.

    • Marco Venniro
    • Matthew L. Banks
    • Yavin Shaham
    Review Article
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Perspectives

  • Major compelling questions about the functional role of the locus coeruleus nucleus that had been difficult to answer, given its remote location and diminutive size, have now become accessible via new neuroscience tools. In this Perspective, 14 investigators provide a historical context for recent discoveries and outline new vistas for investigation.

    • Gina R. Poe
    • Stephen Foote
    • Susan J. Sara
    Perspective
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Correspondence

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