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Neurons expressing corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus of mice show increases and decreases in activity in response to aversive and appetitive stimuli.
Electrical synapses comprise intercellular channels termed gap junctions and are found in vertebrate and invertebrate nervous systems. In this Review, Pepe Alcamí and Alberto Pereda examine the properties of electrical synapses that influence neural circuit dynamics without modifying gap junction conductance.
There is growing evidence for activity-dependent plasticity at inhibitory GABAergic synapses. In this Review, Chiu and colleagues propose that an array of molecular mechanisms promotes the parallel regulation of synapses formed by distinct presynaptic interneurons innervating perisomatic or dendritic targets.
The role of glia in supporting and modulating neuronal activity has been an active area of research. In this Review, Patel et al. discuss the evidence and mechanisms whereby reactivated glia contribute to the development and progression of epilepsy.
Recent studies indicate that cerebellar dysfunction contributes to the aetiology of many neurodevelopmental disorders. In this review, Gallo and colleagues cover recent discoveries in basic cerebellar research, linking them to human imaging and preclinical work on complex brain disorders with motor and non-motor deficits.
