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A mouse model reveals a central role for microglial activation and altered glial cell dynamics in the lasting neurological and cognitive dysfunction following methotrexate chemotherapy.
Repetitive sensory input induces long-term potentiation of pyramidal cell synapses in mouse somatosensory cortex by activation of higher-order thalamic projections and disinhibition of local interneurons.
In addition to the central pacemaker, the mammalian brain contains additional circadian clocks. In this Review, Greco and Sassone–Corsi discuss how systemic homeostasis relies on the coordinated communication between these clocks.
Narcolepsy is a sleep disorder caused by selective loss of orexin-producing neurons. Scammell and colleagues describe the functions of orexin neurons and the effects of their loss and review evidence implicating the immune system in the pathogenesis of the disorder.
Understanding the complex interplay of cells that protect neurons early in Alzheimer disease but later contribute to neurodegeneration is important for developing effective therapeutics. In this Review, Henstridge and colleagues discuss the contributions of multiple cell types to disease pathogenesis.
The core function of sleep remains unclear. In this Opinion, Anafi, Kayser and Raizen give an overview of sleep states in various phyla and propose that the original function of sleep was likely metabolic.
In this Opinion article, Hahn, Kumar and colleagues propose that synchrony- and oscillation-based communication between brain networks can be described by a common theoretical framework. They also suggest a mechanism for control of the flow of information in the brain through nesting of slow and fast oscillations.
