News & Comment

NR1/NR3-containing 'NMDA' receptors are expressedin vivoin myelin and can be activated by glycine alone

regulation of MeCP2 by drugs of abuse contributes to behavioural and neural responses to the drugs

Inhibitors of leucinerich repeat kinase 2 reduce neuronal damage in a mouse model of Parkinson's disease.

Toll-like receptor 3 signalling suppresses hippocampal neurogenesis and impairs working memory.

Ketamine-induced activation of mTOR signalling underlies its antidepressant effects.

tau regulates the interaction of postsynaptic density protein 95 (PSD95) with NMDA (N-methyl-D-aspartate) receptors, which are thought to mediate Aβ toxicity.

translational regulation of E2F1 and DP by miRNAs is implicated in LRRK2-mediated pathogenesis in Parkinson's disease.

Astrocytes control breathing through pH-dependent release of ATP.

SIRT1 modulates synaptic plasticity through microRNA-dependent regulation of the transcription factor cAMP-responsive element-binding (CREB) protein.

Socioeconomic status (SES) influences brain development. Farah and colleagues discuss evidence that prenatal factors, parent–child interactions and cognitive stimulation mediate this effect, and consider implications for alleviating SES-related disparities in mental health and academic achievement.

Mice that experience an enriched environment are more resistant to tumour growth.

New neurons control, through Slit-Robo signalling, the organization of the glial tubes through which they migrate in the RMS.

Signalling by metabotropic glutamate receptor 4 counteracts neuroinflammation in a rodent model of multiple sclerosis.

Genomic imprinting is widespread in the mouse brain and shows sexual dimorphism.

Expression of an exogenous rhodopsin can restore visual function after retinal degeneration in mice.

Dependent on the phosphorylation state of CaMKII at T305/T306 long-term potentiation or long-term depression is induced.