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  • Chronic pain and anxiety may be mechanistically linked by a presynaptic form of long-term potentiation that occurs at synapses in the anterior cingluate cortex.

    • Darran Yates
    Research Highlight

  • A new study shows that boosting mTORC1 activity in the striatum can ameliorate disease phenotypes in a mouse model of Huntington disease.

    • Katherine Whalley
    Research Highlight

  • Activation of nuclear factor-κB in astrocytes leads to the release of complement factor 3, which impairs neuronal function, and this mechanism may contribute to Alzheimer disease.

    • Darran Yates
    Research Highlight

  • The neuregulin 1 receptor ERBB4 tunes synapse strength in the thalamic reticular nucleus as part of a circuit that regulates selective attention.

    • Katherine Whalley
    Research Highlight