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This collection includes recent articles from across the Nature group of journals and showcases both the latest advances in the methodologies used to study genome organization, and our recent understanding of how genome organization and nuclear architecture regulate gene expression, cell fate and cell function in physiology and disease.
Alzheimer disease (AD) is a devastating neurodegenerative disorder that eventually results in dementia. Currently, there are no disease-modifying therapies for AD and the few available symptomatic treatments are of limited benefit. Thus, there is a pressing need to better understand this disease in order to develop effective treatments and to detect the disease in individuals before they exhibit extensive brain atrophy. This article series examines our current understanding of the pathophysiology of AD and some of the approaches being used to study this disease.
The Kavli Prize is awarded by a partnership between the Norwegian Academy of Sciences, the Norwegian Ministry of Education and Research and the Kavli Foundation recognizing seminal work of scientists in astrophysics, nanoscience and neuroscience
Popularization of super-resolution imaging techniques has allowed cell biologists to probe cell structure and function in previously unattainable detail. These methodologies continue to evolve, with new improvements that allow tailoring the available techniques to a particular need and application. This collection showcases primary research articles, reviews and protocols and highlights these recent developments by exemplifying the new, interesting applications of super-resolution microscopy as well as related tool development.
Obesity and metabolic disorders are becoming increasingly prevalent in many parts of the world, and have been accompanied by rising morbidity and associated health costs. This crisis has driven increased research efforts aimed at understanding the neurophysiological systems that regulate food intake and metabolism — and how these systems can become dysfunctional. Nature Reviews Neuroscience presents a series of articles examining various aspects of this regulation in health and disease, including the potential implications for the development of therapies.