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Cell-surface receptors of the Dscam family are required for neuronal wiring inDrosophila. Schmucker discusses the homophilic-binding specificity and diversity of these receptors, their potential role in different aspects of neuronal wiring and key questions that remain unanswered.
Several recent studies have indicated that common neural substrates are involved in remembering past events and imagining future events. Schacter and colleagues outline these findings and discuss the theoretical implications for our understanding of the adaptive functions of memory.
Newly emerging techniques will revolutionize our understanding of the mammalian brain. Deisseroth and colleagues detail the development and use of microbial opsins as optogenetic tools for the study of neural circuits and discuss the use of these tools as potential future therapies for neurological disorders.
