Articles in 2014

In mouse primary visual cortex, subpopulations of layer six principal cells form distinct microcircuits that are involved in visual processing.

Interviews with this year's winners of the Kavli prize in neuroscience, Brenda Milner, John O'Keefe and Marcus Raichle.

It is commonly thought that the dorsal hippocampus is implicated in memory and spatial navigation and the ventral hippocampus in anxiety-related behaviours. On the basis of gene expression, anatomical and electrophysiology studies, Strange and colleagues propose a new model of hippocampal functional anatomy, in which functional long-axis gradients are superimposed on discrete functional domains.

Dynamic regulation of ion concentrations across the cellular membrane is vital for neuronal function. In this article, Kaila and colleagues review the contribution of members of the cation-chloride cotransporters to neuronal signalling, connectivity, plasticity and disease.

The existing properties of neurons in a network restrict its ability to learn to generate new activity patterns.

The emotional valence of a memory can be changed, and this probably involves a change in the connectivity between hippocampal and amygdalar memory traces.

Neurons derived from human induced pluripotent stem cells harbouring a mutation in disrupted in schizophrenia 1 exhibit synaptic deficits.

The application of network science to several common neurological disorders challenges the idea that these disorders are either 'local' or 'global'. In this Review, Kees Stam proposes a model of hub overload and failure as a possible final common pathway in diverse neurological disorders.

Social prejudices and stereotyping are pervasive and often operate unconsciously. In this Review, David M. Amodio considers the neural basis of prejudice and stereotyping and discusses the processes through which such biases may form, can influence behaviour and are regulated.

In mice, miR-34a-mediated downregulation of Notch signalling in the basolateral amygdala enables fear memory consolidation.

Astrocytes contribute to the maintenance of fast synchronous activity in the hippocampus and have a role in recognition memory.

High levels of central transforming growth factor-β1 induce hypothalamic inflammation and lead to hyperglycaemia and glucose intolerance.

A subpopulation of neurons in a subdivision of the central amygdala have been found to mediate diverse anorexigenic signals.