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In the CNS, remyelination of denuded axons occurs to reinstate neuronal function. Franklin and ffrench-Constant consider the cells and molecular signals that are required for remyelination and how this knowledge can be channelled towards more effective therapies for demyelinating diseases.
Silent synapses cannot mediate neurotransmission. Kerchner and Nicoll discuss different mechanisms that have been proposed to underlie synaptic silence, and conclude that LTP and synaptic unsilencing occur by a postsynaptic mechanism that involves AMPA receptor recruitment.
As neuroscience research in Asia undergoes unprecedented growth, collaborations are being established between laboratories in Asia and the West. Four neuroscientists describe their experiences of such collaborations and give their input on the challenges and opportunities that they provide.
The supplementary motor complex has a role in regulating action, but whether each of its subregions has a distinct function is unclear. Husain and colleagues review the literature and discuss outstanding issues regarding the function of this complex.