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A study by Krepleet al. shows that acid-sensitive ion channel 1A in the nucleus accumbens inhibits cocaine-related synaptic plasticity and cocaine-conditioned behaviour in rodents.
Retrotransposons — endogenous DNA sequences that can change their position within the genome — have been found to be active in neurons. Here, Gage and colleagues describe the regulation of retrotransposition in the nervous system and consider its functions in neuronal development, evolution and disease.
Do social decisions and material decisions involve the same neural circuits and computations? In this article, Ruff and Fehr review the social decision-making literature and propose a theoretical framework that may help to address this question.
The ventral temporal cortex (VTC) rapidly and flexibly categorizes visual stimuli. In this Review, Grill-Spector and Weiner discuss how the structural features of the VTC support the computations that are necessary to achieve this categorization.
Malignant gliomas are notoriously difficult cancers to treat. The majority of current therapeutics target the traditional oncological traits of glioma cells. In this Review, Cuddapahet al. explore the unique biology of glioma cells and propose novel, brain-specific therapeutic targets.
Environmental noise is thought to have a negligible influence on the auditory system, but recent data casts doubt on this assumption. In this Opinion article, Gourévitch and colleagues provide their view on how long-term exposure to environmental noise alters the way sound is represented in the adult brain.
Pain-sensitive sensory neurons in the dorsal root ganglion release calcitonin gene-related peptide, which could over time have long-term consequences on metabolism and longevity by reducing pancreatic release of insulin.
