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  • A mismatch between cell adhesion proteins at the mossy fibre synapse drives female-specific synaptic and cognitive dysfunction in a mouse model of developmental and epileptic encephalopathy 9.

    • Katherine Whalley
    Research Highlight
  • Closure of the critical period of a motor circuit in Drosophila melanogaster larvae is regulated by neuroligin–neurexin signalling between astrocytes and motor neurons.

    • Sian Lewis
    Research Highlight
  • The neocortex and the thalamus are connected by looping circuits, enabling cortical function. In this Review, Gordon Shepherd and Naoki Yamawaki examine the patterns of connectivity between the major types of cortical and thalamic neurons and how these cortico-thalamo-cortical loops relate to corticocortical circuits.

    • Gordon M. G. Shepherd
    • Naoki Yamawaki
    Review Article
  • The human hippocampal-entorhinal network supports contextual memory during spatial navigation.

    • Damon Tomlin
    Research Highlight
  • A study shows that reducing tau acetylation protected neurons in a mouse model of traumatic brain injury.

    • Darran Yates
    Research Highlight
  • Evidence suggests that socio-economic status can affect not only the outcome of structural and functional development of the brain but also its rate. Tooley, Bassett and Mackey review this evidence and suggest that the valence and frequency of early experiences interact to influence brain development.

    • Ursula A. Tooley
    • Danielle S. Bassett
    • Allyson P. Mackey
    Perspective
  • Neuroscience can explain cognition by considering single neurons and their connections (a ‘Sherringtonian’ view) or by considering neural spaces constructed by populations of neurons (a ‘Hopfieldian’ view). In this Perspective, Barack and Krakauer argue that the Hopfieldian view has the conceptual resources to explain cognition more fully the Sherringtonian view.

    • David L. Barack
    • John W. Krakauer
    Perspective
  • The impairment of brain fluid homeostasis is a feature of various conditions, highlighting the need to better understand brain water transport for drug development. Here, Nanna MacAulay reviews the molecular mechanisms underlying transmembrane water movement in neurons and glia and across brain barriers, emphasizing the part played by water cotransporters in this process.

    • Nanna MacAulay
    Review Article
  • Dopamine is often portrayed as a diffuse, slow neuromodulator, yet such signalling cannot explain its broad and sometimes rapid roles. Here, Liu, Goel and Kaeser review recent insights into dopamine release and receptors and present a new framework — the domain-overlap model — for dopamine signalling.

    • Changliang Liu
    • Pragya Goel
    • Pascal S. Kaeser
    Review Article
  • In humans, the anterior lateral prefrontal cortex is crucial for assessing the likelihood that a future decision will be correct.

    • Damon Tomlin
    Research Highlight
  • Ion channel dysfunctions contribute significantly to fragile X pathophysiology. In this Review, Deng and Klyachko discuss the mechanisms underlying the effects of these channelopathies in fragile X syndrome, and the therapeutic potential of pharmacological interventions that target ion channels.

    • Pan-Yue Deng
    • Vitaly A. Klyachko
    Review Article
  • Analyses of recurrent neural networks and neural data show how the concept of magnitude is generalized across different contexts.

    • Natasha Bray
    Research Highlight
  • In this Perspective, Koban, Gianaros, Kober and Wager describe neural systems that construct models of the ‘self-in-context’. Such models endow events with personal meaning and enable predictive control over behaviour and peripheral physiology — with implications for health and disease.

    • Leonie Koban
    • Peter J. Gianaros
    • Tor D. Wager
    Perspective
  • TREM2 acts to limit the progression of amyloid-β-driven tau pathology in a mouse model of Alzheimer disease.

    • Katherine Whalley
    Research Highlight
  • Different voltage-gated sodium channels contribute to the transmission of painful information. In this Review, Goodwin and McMahon ask which channels are involved in nociceptor transduction, transmission and transmitter release and why individuals with Nav1.7 null mutations have a painless phenotype.

    • George Goodwin
    • Stephen B. McMahon
    Review Article
  • Dysfunctional GABAergic signalling is common to various neurodevelopmental disorders (NDDs). Tang, Jaenisch and Sur give an overview of the contribution of GABA signalling dysfunction to NDD aetiology and examine how mechanistic insights into such disruption can be used to advance treatments for NDDs.

    • Xin Tang
    • Rudolf Jaenisch
    • Mriganka Sur
    Review Article