Jennie Vallis

On the nature and use of models in network neuroscience

Latest Reviews

  • Review Article |

    The planning and execution of goal-directed actions require numerous decisions to be made, from action selection to the continuous refinement of movement plans. Here, Gallivan et al. discuss these sensorimotor decision-making processes and their interactions with mechanisms of action planning and control.

    • Jason P. Gallivan
    • , Craig S. Chapman
    • , Daniel M. Wolpert
    •  & J. Randall Flanagan
  • Review Article |

    Advanced techniques for the imaging and manipulation of neural circuits are increasingly being used to advance our understanding of psychiatric disorders. Ressler and colleagues describe our current understanding of the circuit dysfunction that underlies the symptoms of post-traumatic stress disorder.

    • Robert J. Fenster
    • , Lauren A. M. Lebois
    • , Kerry J. Ressler
    •  & Junghyup Suh
  • Review Article |

    The gastrointestinal tract is innervated by the enteric nervous system (ENS), and disruption of ENS development can result in various gastrointestinal disorders. Here, Rao and Gershon review the complex processes involved in ENS development, including cell migration, proliferation and organization.

    • Meenakshi Rao
    •  & Michael D. Gershon
  • Review Article |

    Modern network neuroscience involves the use of various types of models to understand the brain. In this Review, Bassett, Zurn and Gold discuss the aims of this approach before examining how network models may be categorized and validated.

    • Danielle S. Bassett
    • , Perry Zurn
    •  & Joshua I. Gold
  • Progress |

    In recent years, several studies have reported the production of microglia-like cells from induced pluripotent stem cells. Pocock and Piers describe the methods used to produce and analyse these cells and their potential to improve our understanding of microglial function.

    • Jennifer M. Pocock
    •  & Thomas M. Piers
  • Review Article |

    Long-term episodic memory storage has been proposed to require a reorganization of neural circuits and networks in a process known as systems consolidation. Tonegawa and colleagues discuss recent advances in our understanding of the contribution of engram cells to this process.

    • Susumu Tonegawa
    • , Mark D. Morrissey
    •  & Takashi Kitamura

News & Comment

  • Research Highlight |

    Spontaneous activity in the developing auditory system is maintained by a homeostatic mechanism and is important for cochlear neuron subtype specification.

    • Katherine Whalley
  • Research Highlight |

    Progressive hyperpolarization of ventricular zone progenitors regulates their sequential differentiation and migration in mouse primary sensory cortex.

    • Sian Lewis
  • Research Highlight |

    Synapse formation and function at hippocampal CA1 synapses are shown to be regulated by three classes of leucine-rich repeat-containing adhesion molecules, which act in a modular manner to regulate spine density and synapse function.

    • Sian Lewis
  • Research Highlight |

    A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival.

    • Darran Yates

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